About 16 results found for searched term "ERK5-IN-5" (0.167 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M49710 | ERK5-IN-5 | ERK |
| ERK5-IN-5 is an ERK5 kinase inhibitor with anticancer activity. | ||
| M4819 | XMD17-109 | ERK |
| ERK5-IN-1 | ||
| XMD17-109 (ERK5-IN-1) is a novel, specific inhibitor of ERK-5 with an EC50 value of 4.2 μM in HEK293 cells. | ||
| M25612 | Elironrasib | Ras |
| RMC-6291 | ||
| Elironrasib is an orally active and covalent inhibitor of KRASG12C(ON). Elironrasib prevents KRASG12C(ON) from signaling via steric blockade of RAS effector binding. Elironrasib inhibits ERK signaling and induced apoptosis in KRASG12C-mutant H358 cells. Elironrasib also inhibits the proliferation of KRASG12C mutant cells with a median IC50 of 0.11 nM. | ||
| M9510 | JWG-071 | ERK |
| JWG-071 is the first reported kinase-selective chemical probe for ERK5, inhibits ERK5 and LRRK2 with IC50 of 88 and 109 nM, respectively. | ||
| M9688 | ERK5-IN-2 | ERK |
| ERK5-IN-2 is a selective, orally active, sub-micromolar ERK5 inhibitor with IC50s of 0.82 μM, 3 μM for ERK5 and ERK5 MEF2D, respectively. | ||
| M14150 | AX-15836 | ERK |
| AX-15836 is a potent and selective ERK5 inhibitor with an IC50 of 8 nM. | ||
| M20811 | XMD8-85 (ERK5-IN-1) | ERK |
| XMD8-85 (ERK5-IN-1) is a selective and potent inhibitor of ERK5 and LRRK2 with IC50s of 0.162 μM and 0.339 μM, respectively. | ||
| M21591 | RLX-33 | RXFP |
| RLX-33 is a potent and selective blood-brain barrier permeable relaxin family peptide 3 (RXFP3) antagonist that also blocks relaxin 3 (Relaxin 3) -induced ERK1/2 phosphorylation. The IC50 phosphorylated RXFP3, ERK1 and ERK2 were 2.36μM, 7.82μM and 13.86μM, respectively. RLX-33 can block the increase of food intake in rats induced by RXFP3 selective agonist R3/I5. RLX-33 can be used in the study of metabolic syndrome. | ||
| M30350 | E6201 | MEK |
| ER-806201 | ||
| E6201 (ER-806201) is an ATP-competitive dual kinase inhibitor of MEK1 and FLT3. E6201 inhibits MEK1- induced ERK2 phosphorylation with an IC50 value of 5.2 nM, MKK4-induced JNK phosphorylation with an IC50 value of 91 nM, and MKK6-induced p38 MAPK phosphorylation with an IC50 value of 19 nM. Anti-tumor and anti-psoriasis efficacy. | ||
| M42116 | ERK-IN-7 | ERK |
| ERK-IN-7, an analogue of SHR2415, is a potent ERK inhibitor with IC50 of 5 nM and 7 nM against ERK1 and ERK2, respectively. | ||
| M42120 | MHJ-627 | ERK |
| MHJ-627 is a potent ERK5 (MAPK7) inhibitor (IC50: 0.91 μM). | ||
| M45287 | CK2/ERK8-IN-1 | Casein Kinase |
| CK2/ERK8-IN-1 is a dual inhibitor of casein kinase 2 (CK2) (Ki 0.25 µM) and ERK8 (MAPK15, ERK7), both with IC50s of 0.50 µM. In addition, CK2/ERK8-IN-1 binds to PIM1, HIPK2, and DYRK1A with Ki values of 8.65 µM, 15.25 µM, and 11.9 µM, respectively. 15.25 µM and 11.9 µM, respectively, and also has pro-apoptotic activity. | ||
| M49696 | ADTL-EI1712 | ERK |
| ADTL-EI1712 is a potent, orally active, and selective dual-target inhibitor of ERK1 and ERK5, inhibition rates of ERK1/5 at 1 μM are 93.54% and 89.35%, respectively. | ||
| M49708 | ERK5-IN-3 | ERK |
| ERK5-IN-3 is a potent and selective ERK5 (extracellular signal-related kinase 5) inhibitor, with an IC50 of 6 nM. | ||
| M49709 | ERK5-IN-4 | ERK |
| ERK5-IN-4 is a potent and selective inhibitor of extracellular signal-related kinase 5 (ERK5). | ||
| M49711 | ERK5-IN-6 | ERK |
| ERK5-IN-6 is an ERK5 kinase inhibitor with anticancer activity. | ||
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
