About 15 results found for searched term "ERK5-IN-5" (0.135 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M49710 | ERK5-IN-5 | ERK |
| ERK5-IN-5 is an ERK5 kinase inhibitor with anticancer activity. | ||
| M4819 | XMD17-109 | ERK |
| ERK5-IN-1 | ||
| XMD17-109 (ERK5-IN-1) is a novel, specific inhibitor of ERK-5 with an EC50 value of 4.2 μM in HEK293 cells. | ||
| M9510 | JWG-071 | ERK |
| JWG-071 is the first reported kinase-selective chemical probe for ERK5, inhibits ERK5 and LRRK2 with IC50 of 88 and 109 nM, respectively. | ||
| M9688 | ERK5-IN-2 | ERK |
| ERK5-IN-2 is a selective, orally active, sub-micromolar ERK5 inhibitor with IC50s of 0.82 μM, 3 μM for ERK5 and ERK5 MEF2D, respectively. | ||
| M14150 | AX-15836 | ERK |
| AX-15836 is a potent and selective ERK5 inhibitor with an IC50 of 8 nM. | ||
| M20811 | XMD8-85 (ERK5-IN-1) | ERK |
| XMD8-85 (ERK5-IN-1) is a selective and potent inhibitor of ERK5 and LRRK2 with IC50s of 0.162 μM and 0.339 μM, respectively. | ||
| M21591 | RLX-33 | RXFP |
| RLX-33 is a potent and selective blood-brain barrier permeable relaxin family peptide 3 (RXFP3) antagonist that also blocks relaxin 3 (Relaxin 3) -induced ERK1/2 phosphorylation. The IC50 phosphorylated RXFP3, ERK1 and ERK2 were 2.36μM, 7.82μM and 13.86μM, respectively. RLX-33 can block the increase of food intake in rats induced by RXFP3 selective agonist R3/I5. RLX-33 can be used in the study of metabolic syndrome. | ||
| M30350 | E6201 | MEK |
| ER-806201 | ||
| E6201 (ER-806201) is an ATP-competitive dual kinase inhibitor of MEK1 and FLT3. E6201 inhibits MEK1- induced ERK2 phosphorylation with an IC50 value of 5.2 nM, MKK4-induced JNK phosphorylation with an IC50 value of 91 nM, and MKK6-induced p38 MAPK phosphorylation with an IC50 value of 19 nM. Anti-tumor and anti-psoriasis efficacy. | ||
| M42116 | ERK-IN-7 | ERK |
| ERK-IN-7, an analogue of SHR2415, is a potent ERK inhibitor with IC50 of 5 nM and 7 nM against ERK1 and ERK2, respectively. | ||
| M42120 | MHJ-627 | ERK |
| MHJ-627 is a potent ERK5 (MAPK7) inhibitor (IC50: 0.91 μM). | ||
| M45287 | CK2/ERK8-IN-1 | Casein Kinase |
| CK2/ERK8-IN-1 is a dual inhibitor of casein kinase 2 (CK2) (Ki 0.25 µM) and ERK8 (MAPK15, ERK7), both with IC50s of 0.50 µM. In addition, CK2/ERK8-IN-1 binds to PIM1, HIPK2, and DYRK1A with Ki values of 8.65 µM, 15.25 µM, and 11.9 µM, respectively. 15.25 µM and 11.9 µM, respectively, and also has pro-apoptotic activity. | ||
| M49696 | ADTL-EI1712 | ERK |
| ADTL-EI1712 is a potent, orally active, and selective dual-target inhibitor of ERK1 and ERK5, inhibition rates of ERK1/5 at 1 μM are 93.54% and 89.35%, respectively. | ||
| M49708 | ERK5-IN-3 | ERK |
| ERK5-IN-3 is a potent and selective ERK5 (extracellular signal-related kinase 5) inhibitor, with an IC50 of 6 nM. | ||
| M49709 | ERK5-IN-4 | ERK |
| ERK5-IN-4 is a potent and selective inhibitor of extracellular signal-related kinase 5 (ERK5). | ||
| M49711 | ERK5-IN-6 | ERK |
| ERK5-IN-6 is an ERK5 kinase inhibitor with anticancer activity. | ||
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