About 6 results found for searched term "Dc1a" (0.12 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M42254 | Dc1a | Sodium Channel |
| Dc1a potently promotes opening of the German cockroach Nav channel (BgNav1). | ||
| M2858 | ML167 | CDK |
| CID 44968231 | ||
| ML167 is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor with IC50 of 136 nM, >10-fold selectivity for closely related kinases Clk1-3 and Dyrk1A/1B. | ||
| M13744 | Dxd | Topoisomerase |
| Exatecan derivative for ADC | ||
| Dxd (Exatecan derivative for ADC) is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a). | ||
| M25028 | Idactamab | Others |
| INT-001 | ||
| Idactamab (INT-001) is an IgG1-κ antibody with in vivo activity across a spectrum of hematological malignancies. Idactamab can be used for prepare MEDI7247, a potent and specific ADC, targeting ASCT2 (SLC1A5). | ||
| M30781 | FTIDC | GluR |
| FTIDC is an orally active, noncompetitive, selective allosteric metabotropic glutamate receptor (mGluR) 1 antagonist with an IC50 of 5.8 nM for human mGluR1a. FTIDC has no species differences in its antagonistic activity on recombinant human, mouse, and rat mGluR1. | ||
| M55227 | T025 | CDK |
| T-025 | ||
| T025 is an orally active and highly potent inhibitor of Cdc2-like kinase (CLKs), with Kd values of 4.8, 0.096, 6.5, 0.61, 0.074, 1.5 and 32 nM for CLK1, CLK2, CLK3, CLK4, DYRK1A, DYRK1B and DYRK2, respectively. | ||
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