About 28 results found for searched term "DYRK" (0.13 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M6478 | AZ Dyrk1B 33 | Others |
| AZ Dyrk1B 33 is a potent and selective Dyrk1B kinase inhibitor. | ||
| M7390 | TC-S 7004 | Others |
| Dyrk1B/A-IN-1 | ||
| TC-S 7004 is a potent and selective DYRK1A/B inhibitor. | ||
| M28808 | Dyrk1A-IN-5 | DYRK |
| Dyrk1A-IN-5 (compound 5j) is a potent and selective DYRK1A inhibitor, with an IC50 of 6 nM. Dyrk1A-IN-5 dose-dependently reduces the phosphorylation of Thr434 in SF3B1, with an IC50 of 0.5 μM. Dyrk1A-IN-5 inhibits phosphorylation of tau at Thr212, with an IC50 of 2.1 μM. Dyrk1A-IN-5 can be used for Down syndrome research. | ||
| M43337 | DYRKtide | Others |
| DYRKtide is a biological active peptide. | ||
| M2765 | ID-8 | DYRK |
| Id-8 is a DYRK inhibitor that maintains the self-renewal of embryonic stem cells in long-term culture. | ||
| M2858 | ML167 | CDK |
| CID 44968231 | ||
| ML167 is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor with IC50 of 136 nM, >10-fold selectivity for closely related kinases Clk1-3 and Dyrk1A/1B. | ||
| M4741 | Harmine-hydrochloride | DYRK |
| Harmine Hydrochloride (Telepathine Hydrochloride) is a DYRK inhibitor with anticancer and anti-inflammatory activities. Harmine Hydrochloride has a high affinity for 5-HT2A serotonin receptor, with a Ki value of 397 nM. | ||
| M5218 | AZ191 | Others |
| AZ191 is a potent small molecule inhibitor that selectively inhibits DYRK1B in vitro and in cells. | ||
| M6787 | Harmine | DYRK |
| Telepathine | ||
| Harmine is a potent and selective DYRK1A inhibitor. | ||
| M6829 | INDY | Others |
| INDY is a dYRK1A/B inhibitor. | ||
| M8272 | BIP-135 | Others |
| BIP-135 is a potent inhibitor of glycogen synthase kinase-3 (GSK3) found to be relatively selective for GSK-3β (21 nM) over GSK-3α with modest activity toward PKCβ (β1: 980 nM; β2: 219 nM), DYRK1B (590 nM), and PI3Kα (870 nM). | ||
| M8642 | FINDY | Others |
| FINDY is a cell-permeable thioxothiazolidinone derivative that specifically targets newly synthesized cellular DYRK1A, but not DYRK1B or DYRK2, for proteasomal degradation by suppressing DYKR1A intramolecular Ser97 autophosphorylation, a necessary event for folding/maturation of newly translated DYRK1A. | ||
| M14888 | EHT 1610 | Others |
| EHT 1610 is a strong inhibitor of DYRK’s family kinases, with IC50s of 0.36, 0.59 nM for DYRK1A and DYRK1B, respectively. | ||
| M14889 | GNF4877 | DYRK |
| GNF4877 is a potent DYRK1A and GSK3β inhibitor with IC50s of 6 nM and 16 nM, respectively, which leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and increased β-cell proliferation (EC50 of 0.66 μM for mouse β (R7T1) cells). | ||
| M21230 | GNF2133 | DYRK |
| GNF2133 is a potent, selective, orally active DYRK1A inhibitor with IC50s of 0.0062 and >50 µM for DYRK1A and GSK3β, respectively. GNF2133 has potential for the study of type 1 diabetes. | ||
| M27658 | GSK-626616 | DYRK |
| GSK-626616 is a potent, orally bioavailable inhibitor of DYRK3 (IC50=0.7 nM). GSK-626616 inhibits other members of the DYRK family (e.g., DYRK1A and DYRK2) with similar potency, which is a potential therapy for the treatment of anemia. | ||
| M27803 | Leucettine L41 | CDK |
| Leucettine L41 is a potent inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A), DYRK2, CDC-like kinase 1 (CLK1), and CLK3 (IC50s = 0.04, 0.035, 0.015, and 4.5 µM, respectively). Leucettine L41 prevents lipid peroxidation and the accumulation of reactive oxygen species (ROS) induced by Aβ25-35 in the hippocampus in a mouse model of Alzheimer’s disease-like toxicity. Leucettine L41 also prevents memory deficits induced by Aβ25-35 in the same model. | ||
| M29094 | HTH-01-091 | MELK |
| HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor, with an IC50 of 10.5 nM. HTH-01-091 also inhibits PIM1/2/3, RIPK2, DYRK3, smMLCK and CLK2. HTH-01-091 can be uesd for breast cancer research. | ||
| M30106 | NU6102 | CDK |
| NU6102 is a potent CDK1 and CDK2 inhibitor with IC50s of 9.5 nM and 5.4 nM for CDK1/cyclinB and CDK2/cyclinA3, respectively. NU6102 shows selectivity for CDK1/CDK2 over CDK4 (IC50 of 1.6 μM), DYRK1A (IC50 of 0.9 μM), PDK1 (IC50 of 0.8 μM) and ROCKII (IC50 of 0.6 μM). | ||
| M39844 | Aristolactam A IIIa | DYRK |
| Aristolactam A IIIa (Sch 546909) is a DYRK1A Inhibitor. Aristolactam A IIIa inhibits platelet aggregation induced by arachidonic acid (AA), collagen and platelet-activating factor (PAF). Aristolactam A IIIa has strong cytotoxic effect on HeLa cells. | ||
| M41418 | Leucettinib-92 | CDK |
| Leucettinib-92 is an inhibitor of DYRK/CLK kinase, The IC50s are 147 nM (CLK1), 39 nM (CLK2), 5.2 nM (CLK4), 0.8 μM (CLK3), 124 nM (DYRK1A), 204 nM (DYRK1B), 0.16 μM (DYRK2), respectively. | ||
| M41423 | CLK1-IN-3 | CDK |
| CLK1-IN-3 is a potent and selective Clk1 inhibitor, with an IC50 of 5 nM and over 300-fold selectivity for Dyrk1A. | ||
| M45287 | CK2/ERK8-IN-1 | Casein Kinase |
| CK2/ERK8-IN-1 is a dual inhibitor of casein kinase 2 (CK2) (Ki 0.25 µM) and ERK8 (MAPK15, ERK7), both with IC50s of 0.50 µM. In addition, CK2/ERK8-IN-1 binds to PIM1, HIPK2, and DYRK1A with Ki values of 8.65 µM, 15.25 µM, and 11.9 µM, respectively. 15.25 µM and 11.9 µM, respectively, and also has pro-apoptotic activity. | ||
| M45292 | TBCA | Casein Kinase |
| TBCA is a highly selective inhibitor of casein kinase II CK2 with an IC50 of 110 nM and a Ki of 77 nM.In addition, TBCA exhibits selectivity for CK1, DYRK1A and 27 other kinases. | ||
| M45316 | ON 108600 | Casein Kinase |
| ON 108600 is an inhibitor of CK2 (Casein Kinase2)/TNIK/DYRK1 with IC50 values of 0.016 μm/0.007 μM, 0.028 μM, 0.05 μM/0.005 μM, and 0.005 μM for DYRK1A/DYRKB, DYRK2, CK2α1/CK2α2, and TNIK, respectively. 0.005 μM. It has anti-tumor activity. | ||
| M49751 | ARN25068 | GSK-3 |
| ARN25068 is a sub-micromolar inhibitor of the three protein kinases, GSK-3β, FYN and DYRK1A to tackle tau hyperphosphorylation. | ||
| M49769 | ZDWX-25 | GSK-3 |
| ZDWX-25 is a highly potent GSK-3β and DYRK1A dual inhibitor with an IC50 value of 71 nM for GSK-3β. | ||
| M50425 | Woodtide | DYRK |
| Woodtide is a substrate for the DYRK (DYRK) family of kinases whose sequence is based on that around the DYRK phosphorylation site in FKHR. | ||
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