About 25 results found for searched term "DNA Methyltransferase" (0.125 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M3008 | SGI-1027 | DNA Methyltransferase |
| DNA Methyltransferase Inhibitor II | ||
| SGI-1027 is a DNMT inhibitor with IC50 of 6, 8, 7.5 μM for DNMT1, DNMT3A, and DNMT3B | ||
| M2182 | RG108 | DNA Methyltransferase |
| N-Phthalyl-L-tryptophan | ||
| RG108 is a novel small-molecule inhibitors of DNA methyltransferases with IC50 of 115 nM. | ||
| M2291 | Azacitidine | DNA/RNA Synthesis |
| 5-azacytidine; Mylosar; Ladakamycin; Vidaza; 5-AzaC; 5-AZA | ||
| Azacitidine is a nucleoside analogue of cytidine that specifically inhibits DNA methylation by trapping DNA methyltransferases. | ||
| M3135 | Zebularine | DNA Methyltransferase |
| NSC309132; 4-Deoxyuridine | ||
| Zebularine is a DNA methylation inhibitor that forms a covalent complex with DNA methyltransferases, also inhibits cytidinedeaminase with Ki of 2 μM. | ||
| M3358 | Procainamide hydrochloride | Sodium Channel |
| Procaine amide hydrochloride; SP 100 hydrochloride | ||
| Procainamide hydrochloride is a sodium channel blocker, and also a DNA methyltransferase inhibitor. | ||
| M7804 | 5-Fluoro-2′-deoxycytidine | Others |
| 5-Fluoro-2′-deoxycytidine is a mechanism based DNMT (DNA cytosine-5 methyltransferase) inhibitor, that forms a covalent link with the cysteine residue in the active site of DNMT. | ||
| M8451 | SW155246 | Others |
| SW155246 is a potent and selective DNMT1 (DNA methyltransferase 1) inhibitor that demethylates cytosines in vivo in a cell-based assay without affecting protein levels or generating reactive oxygen species. | ||
| M8558 | DC_05 | DNA Methyltransferase |
| DC_05 is a potent and selective non-nucleoside DNMT1 (DNA methyltransferase 1) inhibitor that significantly inhibits cancer cell proliferation. | ||
| M8654 | AA-CW236 | Others |
| AA-CW236 is a cell-permeable chloromethyl triazole (CMT) derivative that acts as a non-pseudosubstrate inhibitor against human O(6)-alkylguanine DNA methyltransferase (MGMT) by targeting MGMT active site Cys145 for covalent modification (KI = 24 nM, kinact = 0. | ||
| M10275 | Bobcat339 | DNA Methyltransferase |
| Bobcat-339 | ||
| Bobcat339 is a novel cytosine-based TET enzyme inhibitor with IC50s of 33 and 73 uM for TET1/2, it does not inhibit the DNA methyltransferase DNMT3a. | ||
| M10985 | γ-Oryzanol | DNA Methyltransferase |
| γ-Oryzanol effectively inhibits DNA methyltransferases (DNMTs) in mouse striatum. Suppression of DNMT1 and DNMT3a,IC50 3.2 μM and 22.3 μM, respectively. | ||
| M13816 | Procainamide | DNA Methyltransferase |
| Procaine amide; SP 100 | ||
| Procainamide is a specific and potent inhibitor of DNA methyltransferase 1 (DNMT1). Procainamide is a Class 1A antiarrhythmic agent. Procainamide has the potential for the research of cancer and arrhythmias. | ||
| M21486 | CM-579 trihydrochloride | Histone Methyltransferase |
| CM-579 trihydrochloride is a dual inhibitor of G9a and DNA methyltransferase (DNMT), with IC50 values of 16 nM and 32 nM, respectively, as first-in-class, reversible. It plays an active role in a variety of cancer cells. | ||
| M21488 | CM-579 | Histone Methyltransferase |
| CM-579 is a first-in-class reversible dual inhibitor of G9a and DNA methyltransferase (DNMT) with IC50 values of 16 nM and 32 nM, respectively. It plays an active role in a variety of cancer cells. | ||
| M21595 | Psammaplin A | HDAC |
| Psammaplin A is a Marine metabolite that acts as a potent inhibitor of HDAC and DNA methyltransferases. Psammaplin A is a highly selective HDAC1 inhibitor with an IC50 of 0.9 nM, which is 360 times more selective to HDAC1 than DAC6 and more than 1000 times less potent to HDAC7 and HDAC8. | ||
| M22390 | RX-3117 | Apoptosis |
| Fluorocyclopentenylcytosine; TV-1360 | ||
| RX-3117 (TV-1360) is a potent and orally active anticancer and antimetabolite agent. RX-3117 inhibits DNA methyltransferase 1 (DNMT1). RX-3117 shows antiproliferative and anti-tumour activity. RX-3117 induces cell cycle arrest at S phase and apoptosis. | ||
| M27736 | Lometrexol | Antifolate |
| DDATHF | ||
| Lometrexol (DDATHF), an antipurine antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol can further inhibit de novo purine synthesis, causing abnormal cell proliferation and apoptosis, even cell cycle arrest. Lometrexol has anticancer activity. Lometrexol also is a potent human Serine hydroxymethyltransferase1/2 (hSHMT1/2) inhibitor. | ||
| M27935 | Lometrexol disodium | Antifolate |
| DDATHF disodium | ||
| Lometrexol (DDATHF) disodium, an antipurine antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol disodium can further inhibit de novo purine synthesis, causing abnormal cell proliferation and apoptosis, even cell cycle arrest. Lometrexol disodium has anticancer activity. Lometrexol disodium also is a potent human Serine hydroxymethyltransferase1/2 (hSHMT1/2) inhibitor. | ||
| M28430 | Lometrexol hydrate | Antifolate |
| DDATHF hydrate | ||
| Lometrexol (DDATHF) hydrate, an antipurine antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol hydrate can further inhibit de novo purine synthesis, causing abnormal cell proliferation and apoptosis, even cell cycle arrest. Lometrexol hydrate has anticancer activity. Lometrexol hydrate also is a potent human Serine hydroxymethyltransferase1/2 (hSHMT1/2) inhibitor. | ||
| M30184 | DC_517 | DNA Methyltransferase |
| DC_517 is a DNA methyltransferase 1 (DNMT1) inhibitor, with an IC50 and a Kd of 1.7 μM and 0.91 μM, respectively. | ||
| M30930 | Guadecitabine | DNA Methyltransferase |
| SGI-110 | ||
| Guadecitabine (SGI-110) is a second-generation DNA methyltransferases (DNMT) inhibitor for research of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). | ||
| M38938 | 5-Fluoro-5'-deoxycytidine | Nucleoside Antimetabolite/Analog |
| 5-Fluoro-5'-deoxycytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine), and have potential anti-metabolic and anti-tumor activities. | ||
| M41211 | DNMT-IN-3 | Parasite |
| DNMT-IN-3 is an DNA Methyltransferase (DNMT) inhibitor, and plays an antimalarial role with IC50 of 60 nM against Plasmodium falciparum (Plasmodium). | ||
| M41638 | DNMT2-IN-1 | DNA Methyltransferase |
| DNMT2-IN-1 is a potent and selective DNMT2 (DNA methyltransferase 2) inhibitor with an IC50 value of 1.2 μM, and has the potential for mental and metabolic disorders or cancer research. | ||
| M58409 | CM-444 | HDAC |
| CM-444 is an inhibitor for HDAC and DNA methyltransferases (DNMT) with IC50 values of 6 nM-0.6 μM and 1.8-2.3 μM, respectively. CM-444 is an inducer for the differentiation of acute myeloid leukemia cells. CM-444 exhibits anti-leukemic activity and improves the survival rate in mouse models. | ||
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