About 1 result found for searched term "DGY-09-192" (0.168 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M54696 | DGY-09-192 | PROTAC |
| DGY-09-192 is a bivalent degrader that couples the pan-FGFR inhibitor BGJ398 to the CRL2VHL E3 ligase-recruiting ligand, which induces degradation of FGFR1/2 and largely avoids degradation of FGFR3/4.DGY-09-192 exhibits a nanomolar DC50 against both wild-type FGFR2 and several FGFR2 fusions. In addition, DGY-09-192 has antiproliferative activity in gastric and cholangiocarcinoma cells. | ||
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