About 30 results found for searched term "DC_AC50" (0.129 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M8595 | DC_AC50 | Others |
| DC_AC50 is an inhibitor of copper trafficking proteins Atox1 and CCS, resulting in a disruption of cellular copper transport. | ||
| M1693 | CUDC-101 | HDAC |
| Curis | ||
| CUDC-101 is a potent multitargeted HDAC, EGFR and HER2 inhibitor with IC50 of 4.4, 2.4, and 15.7 nM, respectively. | ||
| M2111 | Fimepinostat | HDAC |
| CUDC-907 | ||
| Fimepinostat (CUDC-907) is a potent, orally-available small molecule dual PI3K and HDAC inhibitor, with IC50 values of 19/54/39 nM and 1.7/5.0/1.8/2.8 nM for PI3Kα/PI3Kβ/PI3Kδ and HDAC1/HDAC2/HDAC3/HDAC10, respectively. | ||
| M3668 | GDC-0994 | ERK |
| Ravoxertinib | ||
| Ravoxertinib (GDC-0994) is an orally active ERK kinase inhibitor with IC50 of 6.1 nM and 3.1 nM against ERK1 and ERK2, respectively. | ||
| M10761 | DC260126 | Apoptosis |
| DC260126 is a potent GPR40 (FFAR1) antagonist. DC260126 dose-dependent inhibits GPR40-mediated Ca of linoleic acid, oleic acid, palm oleic acid, and lauric acid irritation2+ ELEVATED (IC50 6.28, 5.96, 7.07, 4.58 μM, respectively). DC260126 is protective of palmitate-induced endoplasmic reticulum stress and apoptosis ( apoptosis ) . | ||
| M11235 | Recombinant Human PD-1 Protein(Fc) | Cytokines and Growth Factors |
| CD279; PDCD1 | ||
| Pd-1 (Programmed Cell death protein 1), also known as PDCD1, is an important immunosuppressive transmembrane protein expressed on the surface of T cells. The protein Sequence of this product is the expression of DNA Sequence encoding human PD-1 (NCBI Reference Sequence: NP_005009.2) with Fc label at the C-terminal. | ||
| M11442 | Divarasib | Ras |
| GDC-6036 | ||
| Divarasib (GDC-6036) is an orally active, selective, covalently mutated KRAS G12C inhibitor with an IC50<0.01 μM for K-Ras G12C. GDC-6036 has an EC50 of 2 nM in K-Ras G12C-alkylated HCC1171 cells. can be used in studies related to non-small cell lung cancer ( NSCLC) related studies. | ||
| M11516 | Vimseltinib | CSF-1R (c-Fms) |
| DCC-3014 | ||
| Vimseltinib (DCC-3014) is a highly selective, orally active inhibitor of colony-stimulating factor-1 receptor (CSF-IR) and c-Kit with IC50 values of <0.01 μM and 0.1-1 μM, respectively.Vimseltinib is used in studies related to tenosynovial giant cell tumors (TGCT). | ||
| M13379 | Guggulsterone | Apoptosis |
| Z/E-Guggulsterone | ||
| Guggulsterone is a plant sterol from the gum fat of the Commiphora Wightii tree. Guggulsterone is a farnesoid X receptor (FXR) antagonist, decreases CDCA-induced FXR activation with IC50s of 17 and 15 μM for Z- and E-Guggulsterone, respectively. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt. | ||
| M14153 | Ravoxertinib hydrochloride | ERK |
| GDC-0994 hydrochloride | ||
| Ravoxertinib hydrochloride (GDC-0994 hydrochloride) is an orally bioavailable inhibitor selective for ERK kinase activity with IC50 of 6.1 nM and 3.1 nM for ERK1 and ERK2, respectively. | ||
| M14881 | GDC-0834 Racemate | BTK |
| GDC-0834 Racemate is the racemate form of GDC-0834, which is a potent and selective BTK inhibitor with in vitro IC50s of 5.9 and 6.4 nM in biochemical and cellular assays, respectively. | ||
| M18932 | α-Spinasterol | TRP Channel |
| α-Spinasterol is a transient receptor potential vanilloid 1 (TRPV1) antagonist, has anti-inflammatory, antidepressant, antioxidant and antinociceptive effects. α-Spinasterol inhibits COX-1 andCOX-2 activities with IC50 values of 16.17 μM and 7.76 μM, respectively. | ||
| M20714 | NAcM-OPT | E1/E2/E3 Enzyme |
| NAcM-OPT is a specific, reversible and orally bioavailable inhibitor of cullin neddylation 1 (DCN1) that targets N-Acetyl-UBE2M (E2 conjugating enzyme, UBC12) interaction with DCN1 with IC50 of 79 nM. | ||
| M21042 | DCPIB | Potassium Channel |
| DCPIB is a specific and potent inhibitor of volume-regulated anion channels (VRAC). DCPIB potently inhibits several K2P channels with no voltage dependence, including TRESK, TASK1, and TASK3. DCPIB displayed superior selectivity toward TRESK with an IC50 of 0.14 μM. | ||
| M21126 | GDC-0310 | Sodium Channel |
| GDC-0310 is a selective Nav1.7 acyl sulfonamide inhibitor with an IC50 value of 0.6 nM for hNav1.7. It is an oral primary clinical candidate for the study of pain. | ||
| M21393 | TCMDC-135051 | Others |
| TCMDC-135051 is a highly selective and potent inhibitor of the protein kinase PfCLK3 with low off-target toxicity.TCMDC-135051 prevents trophozoite to lytic transition, disrupts transcription and reduces transmission to mosquito vectors.TCMDC-135051 has antiparasitic activity (EC50=320 nM). | ||
| M21531 | GDC-2394 | NLR |
| GDC-2394 is an oral inhibitor of NLRP3 inflammasome. The NLRP3 inflamome, the best studied and most characterized, also inhibits IL-1β with IC50 of 0.4 μM (human IL-1β) and 0.1 μM (mouse IL-1β). | ||
| M27863 | DC07090 dihydrochloride | Anti-infection |
| DC07090 dihydrochloride is a low toxicity, potent, reversible and competitive non-peptidyl human enterovirus 71 3C protease inhibitor with an IC50 and a Ki value for 21.72 μM and 23.29 μM. DC07090 dihydrochloride could also inhibit coxsackievirus A16 (CVA16) replication with an EC50 value of 27.76 μM. | ||
| M27916 | GDC0575 hydrochloride | Checkpoint |
| ARRY-575 hydrochloride; RG7741 hydrochloride | ||
| GDC0575 (ARRY-575) hydrochloride is a highly-selective and orally active Chk1 (IC50=1.2 nM) inhibitor. GDC0575 (ARRY-575) hydrochloride can be used for colitis-associated cancer (CAC) and colitis research. | ||
| M28229 | KH-CB19 | CDK |
| KH-CB19 is a potent CLK (cdc2-like kinase) inhibitor (CLK1 IC50=19.7 nM; CLK3 IC50=530 nM). KH-CB19 shows antiviral activity and inhibits influenza virus replication (IC50=13.6 μM). | ||
| M28535 | GDC-0276 | Sodium Channel |
| GDC-0276 is a potent, selective, reversible and orally active NaV1.7 inhibitor with an IC50 value of 0.4 nM. GDC-0276 is well tolerated and exhibits a good pharmacokinetic profile. GDC-0276 has the potential for the treatment of pain and to address shortcomings of existing pain medications, such as addiction and off-target side effects. | ||
| M29136 | PROTAC TBK1 degrader-2 | PROTAC |
| PROTAC TBK1 degrader-2 is a Ligands for Target Protein for PROTAC. PROTAC TBK1 degrader-2 is a potent degrader based on the serine/threonine kinase TANK-binding kinase 1 (TBK1) (DC50=15 nM; Kd=4.6 nM) with a maximum efficiency of 96%. PROTAC TBK1 degrader-2 also targets to IkB kinase IKKε (IC50=8.7 nM), with low selectivity over TBK1 (IC50=1.3 nM). | ||
| M29432 | WS-383 free base | E1/E2/E3 Enzyme |
| WS-383 free base is a potent, selective and reversible inhibitor of DCN1-UBC12 interaction, with an IC50 of 11 nM. WS-383 free base inhibits Cul3/1 neddylation, induces accumulation of p21, p27 and NRF2. | ||
| M29433 | WS-383 | E1/E2/E3 Enzyme |
| WS-383 is a potent, selective and reversible inhibitor of DCN1-UBC12 interaction, with an IC50 of 11 nM. WS-383 inhibits Cul3/1 neddylation, induces accumulation of p21, p27 and NRF2. | ||
| M29568 | M2N12 | CDK |
| M2N12 is a potent and highly selective cell division cycle 25C protein phosphatase (Cdc25C) inhibitor with an IC50 value of 0.09 μM. M2N12 also has promising activity against Cdc25A and Cdc25B with IC50 values of 0.53 μM and 1.39 μM, respectively. M2N12 has anti-tumor activity and can be used for cancer research. | ||
| M30781 | FTIDC | GluR |
| FTIDC is an orally active, noncompetitive, selective allosteric metabotropic glutamate receptor (mGluR) 1 antagonist with an IC50 of 5.8 nM for human mGluR1a. FTIDC has no species differences in its antagonistic activity on recombinant human, mouse, and rat mGluR1. | ||
| M31276 | PROTAC CDK2/9 Degrader-1 | PROTAC |
| PROTAC CDK2/9 Degrader-1 is a potent dual degrader for CDK2 (DC50=62 nM) and CDK9 (DC50=33 nM). PROTAC CDK2/9 Degrader-1 suppresses prostate cancer PC-3 cell proliferation (IC50=0.12 µM) by effectively blocking the cell cycle in S and G2/M phases. PROTAC CDK2/9 Degrader-1 is a PROTAC by tethering CDK inhibitor with Cereblon ligand. | ||
| M41647 | DC-BPi-11 hydrochloride | Epigenetic Reader Domain |
| DC-BPi-11 hydrochloride is an inhibitor of bromodomain PHD finger transcription factor (BPTF), with an IC50 value of 698 nM. | ||
| M43441 | PROTAC GPX4 degrader-1 | PROTAC |
| PROTAC GPX4 degrader-1 (DC-2) is a PROTAC-based GPX4 degrader, with a DC50 of 0.03 μM in HT1080 cells. | ||
| M58581 | MS4322 | PROTAC |
| YS43-22 | ||
| MS4322 (YS43-22) is a specific PRMT5 PROTAC degrader. MS4322 reduces the PRMT5 protein level with a DC50 of 1.1 μM in MCF-7 cells. MS4322 inhibits the methyltransferase activity of PRMT5 with an IC50 of 18 nM. MS4322 promotes ubiquitination and degradation of PRMT5. | ||
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
