About 9 results found for searched term "Cholesterol-d7" (0.135 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M22127 | Cholesterol-d7 | Others |
| Cholesterol-d7 | ||
| M18414 | 7-Dehydrocholesterol | Ferroptosis |
| 7-DHC | ||
| 7-Dehydrocholesterol (7-DHC) is a metabolic intermediate in cholesterol synthesis as well as an unsaturated sterol whose conjugated double bond on the sterol's B ring allows 7-DHC to take up free radicals, thereby counteracting the ability of free radicals to trigger lipid oxidation and iron death. | ||
| M28685 | Cholesterol 24-hydroxylase-IN-1 | Cytochrome P450 (e.g. CYP17) |
| Cholesterol 24-hydroxylase-IN-1 (compound 17) is a potent, orally active, and highly selective cholesterol 24-hydroxylase (CH24H or CYP46A1) inhibitor (IC50=8.5 nM). Cholesterol 24-hydroxylase-IN-1 can cross blood-brain barrier. | ||
| M28935 | YM-53601 free base | Farnesyl Transferase |
| YM-53601 free base, a squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in vivo. YM-53601 free base inhibits squalene synthase derived from human hepatoma cells with an IC50 of 79 nM. Lipid-lowering agent. YM-53601 free base is also an inhibitor of farnesyl-diphosphate farnesyltransferase 1 (FDFT1) enzyme activity and abrogates HCV propagation. | ||
| M28936 | YM-53601 | Farnesyl Transferase |
| YM-53601, a squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in vivo. YM-53601 inhibits squalene synthase derived from human hepatoma cells with an IC50 of 79 nM. Lipid-lowering agent. YM-53601 is also an inhibitor of farnesyl-diphosphate farnesyltransferase 1 (FDFT1) enzyme activity and abrogates HCV propagation. | ||
| M30030 | 7α-Hydroxy-4-cholesten-3-one | Metabolite/Endogenous Metabolite |
| 7α-Hydroxy-4-cholesten-3-one is an intermediate in synthesis of bile acids from cholesterol. 7α-Hydroxy-4-cholesten-3-one is a pregnane X receptor (PXR) agonist. 7α-Hydroxy-cholest-4-en-3-one is a biomarker for bile acid loss, irritable bowel syndrome, and other diseases associated with defective bile acid biosynthesis. 7α-Hydroxy-cholest-4-en-3-one is the physiological substrate for CYP8B1. | ||
| M30042 | Cholesterol 5beta,6beta-epoxide | Others |
| Cholesterol beta-epoxide | ||
| Cholesterol 5beta,6beta-epoxide is an oxidative metabolite of cholesterol formed by free-radical and non-radical oxidation of cholesterol at the 5,6 double bond. Cholesterol 5beta,6beta-epoxide induces lactate dehydrogenase (LDH) release and apoptosis in macrophage-differentiated U937 cells. | ||
| M30428 | 7α,25-Dihydroxycholesterol | GPR/FFAR |
| 7α, 25-dihydroxycholesterol (7α,25-OHC) is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183). 7α, 25-dihydroxycholesterol is highly potent at activating EBI2 (EC50=140 pM; Kd=450 pM). 7α, 25-dihydroxycholesterol can serve as a chemokine directing migration of B cells, T cells and dendritic cells. | ||
| M39737 | 7β-Hydroxycholesterol | Others |
| 7β-Hydroxycholesterol is an oxysterol that derived by the oxidation of cholesterol. 7β-hydroxycholesterol is a powerful inducer of oxidative stress, inducing dysfunction of organelles (mitochondria, lysosomes and peroxisomes) that can cause cell death. | ||
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