About 2 results found for searched term "Capmatinib hydrochloride" (0.129 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M40733 | Capmatinib hydrochloride | c-Met |
| INC280 hydrochloride; INCB-28060 hydrochloride | ||
| Capmatinib hydrochloride is a potent, orally active, selective, ATP-competitive c-Met kinase inhibitor that inhibits the phosphorylation of c-MET and downstream effector proteins of the c-MET pathway, with an IC50 value of 0.13 nM. In addition, Capmatinib hydrochloride In addition, Capmatinib hydrochloride can inhibit the proliferation and migration of c-Met-dependent tumor cells, and can effectively induce apoptosis (apoptosis), with anti-tumor activity. | ||
| M54609 | Capmatinib dihydrochloride hydrate | c-Met |
| INC280 dihydrochloride hydrate; INCB-28060 dihydrochloride hydrate | ||
| Capmatinib dihydrochloride hydrate is a potent, orally active, selective, ATP-competitive c-Met kinase inhibitor (IC50=0.13 nM) that inhibits the phosphorylation of c-MET, as well as downstream effector proteins of the c-MET pathway, such as ERK1/2, AKT, FAK, In addition, Capmatinib dihydrochloride hydrate effectively inhibited the proliferation and migration of c-Met-dependent tumor cells, induced apoptosis, and demonstrated antitumor activity in a mouse model of tumor. Capmatinib dihydrochloride hydrate is mainly metabolized by CYP3A4 and aldehyde oxidase. | ||
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