About 2 results found for searched term "CX-5461" (0.212 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2293 | CX-5461 | DNA/RNA Synthesis |
| Pidnarulex | ||
| CX-5461 (Pidnarulex) selectively inhibits Pol I-driven transcription of rRNA with IC50 of 142 nM in HCT-116 cells. | ||
| M13642 | CX-5461 dihydrochloride | DNA/RNA Synthesis |
| CX-5461 dihydrochloride is a potent and orally bioavailable inhibitor of Pol I-mediated rRNA synthesis, with IC50s of 142 nM in HCT-116, 113 nM in A375, and 54 nM in MIA PaCa-2 cells, and shows little or no effect on Pol II (IC50 ≥25 μM). | ||
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