About 4 results found for searched term "CH 275" (0.126 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M3483 | Flavopiridol hydrochloride | CDK |
| NSC 649890 HCl; Alvocidib hydrochloride; L86 8275 HCl; HMR-1275 HCl | ||
| Flavopiridol competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM. It is 7.5-fold more selective for CDK1/2/4/6 than CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. | ||
| M54030 | CH 275 | Somatostatin Receptor |
| CH 275 is a peptide analog of somatostatin and binds preferably to somatostatin receptor 1 (sst1) with a Ki of 52 nM. | ||
| M1942 | Alectinib | ALK |
| CH5424802; AF802 | ||
| Alectinib (CH5424802) is a highly selective, orally active and potent ALK inhibitor with IC50 of 1.9 nM. Alectinib (CH5424802) also inhibits ALK F1174L and ALK R1275Q with IC50s of 1 nM and 3.5 nM, respectively. Alectinib demonstrates effective central nervous system (CNS) penetration. | ||
| M6082 | 2,6-Dichloro-3,5-dimethoxyaniline | Others |
| 2,6-Dichloro-3,5-dimethoxyaniline is H3B-6275 intermediate. | ||
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