About 12 results found for searched term "BT-11" (0.122 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M6389 | 1-Aminobenzotriazole (ABT) | Cytochrome P450 (e.g. CYP17) |
| ABT; 3-Aminobenzotriazole; 1-Benzotriazolylamine; NSC 114498; NSC 656987 | ||
| 1-Aminobenzotriazole (ABT) is a cytochrome P450 inhibitor; inhibits 20-HETE synthesis. | ||
| M20955 | BT-11 | Others |
| BT-11 is an orally active lanthionine synthetase C-like 2 (LANCL2) binding compound for treating inflammatory bowel disease (IBD) (Kd value of 7.7 µM). | ||
| M42998 | GBT1118 | Others |
| GBT1118 is a potent and orally active allosteric modifier of hemoglobin oxygen affinity. | ||
| M3109 | UNC669 | Epigenetic Reader Domain |
| UNC669 is a potent and selective MBT (malignant brain tumor) inhibitor with IC50 of 6 μM for L3MBTL1, 5- and 11-fold selective over L3MBTL3 and L3MBTL4. | ||
| M8887 | Btk inhibitor 2 | BTK |
| BGB-3111 | ||
| Btk inhibitor 2 (BGB-3111) is a Brutons tyrosine kinase (BTK) inhibitor. | ||
| M18258 | 11beta,13-Dihydrolactucin | Immunology/Inflammation |
| 11beta,13-Dihydrolactucin is a sesquiterpene lactone obtained by formal hydrogenation across the 11,13-double bond of lactucin. Found in chicory It has a role as a plant metabolite. | ||
| M20631 | BTK inhibitor 1 (Compound 27) | BTK |
| BTK inhibitor 1 (compound 27) is an inhibitor of BTK with an IC50 of 0.11 nM for Btk and inhibits B cell activation in hWB with an IC50 of 2 nM. | ||
| M21654 | BTRX-335140 | Opioid Receptor |
| CYM-53093 | ||
| BTRX-335140 is a selective and orally active κ opioid receptor (KOR) antagonist, has antagonist activity for κOR, μOR and δOR with IC50 values of 0.8 nM, 110 nM, and 6500 nM, respectively. Navacaprant endows with favorable in vitro ADMET and in vivo pharmacokinetic profiles and medication-like duration of action in rats. | ||
| M30111 | ABT-100 | Farnesyl Transferase |
| ABT-100 is a potent, highly selective and orally active farnesyltransferase inhibitor. ABT-100 inhibits cell proliferation (IC50s of 2.2 nM, 3.8 nM, 5.9 nM, 6.9 nM, 9.2 nM, 70 nM and 818 nM for EJ-1, DLD-1, MDA-MB-231, HCT-116, MiaPaCa-2, PC-3, and DU-145 cells, respectively), increases apoptosis and decreases angiogenesis. ABT-100 possesses broad-spectrum antitumor activity. | ||
| M30757 | ABT-384 | Hydroxysteroid dehydrogenase |
| ABT-384 is a potent, selective 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor. ABT-384 exhibits high affinity (Ki 0.1-2.7 nM) against rodent, monkey, and human 11β-HSD1. ABT-384 blocks regeneration of active cortisol. ABT-384 can be used for the research of Alzheimer’s disease (AD). | ||
| M38654 | 4-Methylherniarin | Antibiotic |
| 4-Methylherniarin (7-Methoxy-4-methylcoumarin) has an antimicrobial activitiy against both gram positive and gram negative bacterial stains. 4-Methylherniarin displays good activity against B. subtilis and S.sonnei with IC50 values of 11.76 ug/ml and 13.47 ug/ml. | ||
| M40519 | AOH1996 | DNA/RNA Synthesis |
| AOH1996 is an orally active small molecule PCNA inhibitor, which can be obtained by adding a methoxy group to the interstitial position of the benzene ring at the end of AOH1160, and enhances the interaction between PCNA and RPB1, the largest subunit of RNA polymerase II, as well as selectively kills cancer cells, which can be used in cancer-related research. | ||
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