About 1 result found for searched term "BI-4020" (1.024 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M40639 | BI-4020 | EGFR/HER2 |
| BI-4020 is a fourth-generation, orally active, non-covalent EGFR tyrosine kinase macrocyclic inhibitors (TKIs). It inhibits the triple mutant EGFR del19 T790M C797S mutant (IC50=0.2 nM in the BaF3 cell line), the double mutant EGFR del19 T790M, and the single mutant EGFR del19 (IC50=1 nM). and also retains activity against EGFR wt (IC50=190 nM), which can be used in studies related to non-small cell lung cancer (NSCLC). | ||
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