About 3 results found for searched term "BI-4020" (0.138 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M40639 | BI-4020 | EGFR/HER2 |
| BI-4020 is a fourth-generation, orally active, non-covalent EGFR tyrosine kinase macrocyclic inhibitors (TKIs). It inhibits the triple mutant EGFR del19 T790M C797S mutant (IC50=0.2 nM in the BaF3 cell line), the double mutant EGFR del19 T790M, and the single mutant EGFR del19 (IC50=1 nM). and also retains activity against EGFR wt (IC50=190 nM), which can be used in studies related to non-small cell lung cancer (NSCLC). | ||
| M1884 | Triciribine | Akt |
| API-2, NSC 154020, TCN | ||
| Triciribine (API-2, NSC 154020) is a selective inhibitor of Akt (protein kinase B) signaling with IC50 of 130 nM. | ||
| M30844 | CPUY074020 | Histone Methyltransferase |
| CPUY074020 is a potent and oral bioavailable inhibitor of histone methyltransferase G9a, with an IC50 of 2.18 μM. CPUY074020 possesses anti-proliferative activity. | ||
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