Astin B - Search Results | AbMole BioScience

About 5 results found for searched term "Astin B" (0.054 seconds)

Cat.No.	Name	Target
M1702	DCC-2036	Src-bcr-Abl
	Rebastinib
	DCC-2036 is an ABL inhibitor with IC50 of 0.8 and 2 nM for u-ABL1native and p-ABL1native, respectively.
M2449	Bepotastine Besilate	Histamine Receptor
	Bepotastine is a non-sedating, selective antagonist of histamine 1 (H1) receptor with pIC50 of 5.7.
M20720	Vindesine sulfate	Microtubule
	Eldesine, Eldisine, Desacetyl Vinblastine amide, Desacetylvinblastine amide, DAVA, DVA, VDS
	Vindesine sulfate (Eldesine, Eldisine, Desacetyl Vinblastine amide, Desacetylvinblastine amide, DAVA, DVA, VDS), a vinca alkaloid derived from Catharanthus roseus, is a potent inhibitor of mitosis with antineoplastic activities. Vindesine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death.
M28692	Bezuclastinib	c-Kit
	CGT9486; PLX 9486
	Bezuclastinib (CGT9486; PLX 9486) is a potent inhibitor of c-kit and c-kit D816V (0.0001 < IC50 < 1 μM). Bezuclastinib is a tyrosine kinase inhibitor.
M38852	Astin B	Apoptosis
	Astin B is a orally active and potent cyclic pentapeptide, that has hepatotoxic effects in vitro and in vivo and that hepatic injury was primarily mediated by apoptosis in a mitochondria/caspase-dependent manner. Astin B induces autophagy in L-02 cells, increases LC3-II and decreases p62 expression.