About 30 results found for searched term "Aryl hydrocarbon Receptor" (0.125 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M4699 | Galangin | Cytochrome P450 (e.g. CYP17) |
| 3,5,7-Trihydroxyflavone; Norizalpinin | ||
| Galangin (Norizalpinin) is a regulator of arylhydrocarbon receptors and also inhibits the activity of CYP1A1. | ||
| M7727 | CH-223191 | Aryl hydrocarbon Receptor |
| CH223191 | ||
| CH-223191 is a potent and specific aryl hydrocarbon receptor (AhR) antagonist. CH-223191 inhibits TCDD-mediated nuclear translocation and DNA binding of AhR, and inhibits TCDD-induced luciferase activity with an IC50 of 0.03 μM. *The compound is unstable in solutions, freshly prepared is recommended | ||
| M8225 | DiMNF | Others |
| DiMNF is a naphthoflavone derivative, selective aryl hydrocarbon receptor modulator (SAhRM). | ||
| M8310 | CHD-5 | Others |
| CHD-5 is a potent aryl hydrocarbon receptor antagonist. | ||
| M8670 | 10-Cl-BBQ | Others |
| 10-Cl-BBQ is an orally bioavailable, non-toxic benzimidazoisoquinoline derivative that acts as an aryl hydrocarbon receptor (AhR) agonist via directly binding to AhR (IC50 = 2. | ||
| M8806 | 6, 2′, 4′-trimethoxyflavone | Others |
| 6, 2′, 4′-trimethoxyflavone is a selective aryl hydrocarbon receptor (AHR) antagonist with no partial agonist activity. | ||
| M8862 | YH439 | Aryl hydrocarbon Receptor |
| Mivotilate | ||
| Mivotilate (YH439) is a potent activator of the aryl hydrocarbon receptor (AhR). | ||
| M9358 | ITE | Immunology/Inflammation |
| ITE is a potent endogenous agonist of aryl hydrocarbon receptor (AhR), which directly binding to AHR with a Ki of 3 nM. | ||
| M9693 | PDM2 | Aryl hydrocarbon Receptor |
| PDM-2 | ||
| PDM2 is a potent and selective aryl hydrocarbon receptor (AhR) antagonist, with a Ki of 1.2 nM. | ||
| M9714 | CAY10465 | Aryl hydrocarbon Receptor |
| CAY-10465 | ||
| CAY10465 is an analog of resveratrol acting as a potent and selective aryl hydrocarbon receptor agonist, with a Ki of 0.2 nM. | ||
| M9723 | L-Kynurenine | Aryl hydrocarbon Receptor |
| L-Kynurenine is an aryl hydrocarbon receptor agonist. | ||
| M10486 | GNF351 | Aryl hydrocarbon Receptor |
| GNF351 is a full aryl hydrocarbon receptor (AHR) antagonist. GNF351 competes with a photoaffinity AHR ligand for binding to the AHR with an IC50 of 62 nM. | ||
| M11147 | Skatole | Aryl hydrocarbon Receptor |
| 3-Methylindole | ||
| Skatole is a substance produced by the intestinal flora that regulates intestinal epithelial cell function by activating aryl hydrocarbon receptors and p38. | ||
| M14102 | Cardamonin | NLR |
| Cardamomin; Alpinetin chalcone | ||
| Cardamonin (Cardamomin) acts as an aryl hydrocarbon receptor (AhR) activator. Cardamonin alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway. | ||
| M14603 | Indole-3-carbinol | NF-κB |
| I3C; 3-Indolemethanol | ||
| Indole-3-carbinol (I3C) inhibits NF-κB activity and also is an Aryl hydrocarbon receptor (AhR) agonist, and an inhibitor of WWP1 (WW domain-containing ubiquitin E3 ligase 1). | ||
| M20404 | Tryptamine | TAAR |
| Tryptamine is a monoamine alkaloid and may play a role as a neuromodulator or neurotransmitter. It is an agonist of hTAAR1. It acts as a non-selective serotonin receptor agonist and serotonin-norepinephrine-dopamine releasing agent (SNDRA). Tryptamine is a selective, blood-brain-penetrating 5-HT4 receptor agonist (EC50=1-3 mM) and an endogenous ligand of the aryl hydrocarbon receptor (AHR) (Kd=10-50 nM). Tryptamine promotes intestinal anion secretion and fluid transport by activating G protein-coupled receptors (GPCRs). | ||
| M20517 | Minaprine dihydrochloride | Aryl hydrocarbon Receptor |
| activate the aryl hydrocarbon receptor (AhR) signaling pathway | ||
| M20602 | UM729 | Aryl hydrocarbon Receptor |
| C07 | ||
| UM729 is an enhancer of aryl hydrocarbon receptor (AhR) antagonists. | ||
| M20977 | BAY 2416964 | Aryl hydrocarbon Receptor |
| BAY 2416964 (compound 192) is a potent and orally active antagonist of aryl hydrocarbon receptor (AhR) with IC50 of 341 nM. BAY 2416964 has the potential in the treatment of solid tumors. | ||
| M21232 | MeBIO | GSK-3 |
| 6-bromoindirubin-3'-oxime | ||
| MeBIO, an analog of 6-bromoindirubin-3'-oxime, has been suggested to possess the structural basis for a potent and selective inhibitor of glycogen synthase kinase-3 (GSK3) and cyclin-dependent kinases. MeBIO displays minimal activity against CDK1/Cyclin B, GSK-3, and CDK5/p25 (IC50 values are 92.0, 44-100 and >100 μM respectively). MeBIO is a potent AhR (aryl hydrocarbon receptor) agonist. | ||
| M25481 | β-Naphthoflavone | Aryl hydrocarbon Receptor |
| 5,6-Benzoflavone; beta-NF | ||
| β-Naphthoflavone is an aryl hydrocarbon receptor (AhR) agonist, used as a positive control for the induction of AhR transcriptional activity. β-Naphthoflavone inhibits hydrogen peroxide-induced apoptosis. | ||
| M25533 | Carbidopa monohydrate | Aryl hydrocarbon Receptor |
| Carbidopa monohydrate is a dopa decarboxylase (DDC) inhibitor, which can be used for the research of Parkinson's disease. Carbidopa monohydrate is also a selective aryl hydrocarbon receptor (AhR) modulator. | ||
| M27622 | 1,4-Chrysenequinone | Aryl hydrocarbon Receptor |
| Chrysene-1,4-dione | ||
| 1,4-Chrysenequinone, a polycyclic aromatic quinone, acts as an activator of aryl hydrocarbon receptor (AhR). | ||
| M29582 | β-NF-JQ1 | PROTAC |
| β-NF-JQ1 is a PROTAC that recruits Aryl Hydrocarbon Receptor E3 ligase to target proteins. β-NF-JQ1 is directed against bromodomain-containing (BRD) proteins using β-NF as an AhR ligand, induces the interaction of AhR and BRD proteins, and displays effective anticancer activity that correlated with protein knockdown activity. | ||
| M38970 | Benzyl butyl phthalate | Aryl hydrocarbon Receptor |
| Benzyl butyl phthalate can trigger the migration and invasion of hemangioma (HA) cells via upregulation of Zeb1. Benzyl butyl phthalate activates aryl hydrocarbon receptor (AhR) in breast cancer cells to stimulate SPHK1/S1P/S1PR3 signaling and enhances formation of metastasis-initiating breast cancer stem cells (BCSCs). | ||
| M41280 | AHR agonist 3 | Apoptosis |
| AHR agonist 3 is an aryl hydrocarbon receptor (AhR) agonist, that can induces cell cycle arrest or apoptosis via activation of tumor-suppressive transcriptional programs. | ||
| M41956 | AHR agonist 4 | Aryl hydrocarbon Receptor |
| AHR agonist 4 is an agonist of Aryl hydrocarbon receptor (AHR), assocaited with the immune balance of Th17/22 and Treg cells. | ||
| M42309 | hCYP1B1-IN-1 | Cytochrome P450 (e.g. CYP17) |
| hCYP1B1-IN-1 is a hCYP1B1 inhibitor (IC50=3.6 nM), as well as an antagonist of Aryl Hydrocarbon Receptor. | ||
| M49463 | 3-Methylcholanthrene | Animal Modeling |
| 3-MCT | ||
| 3-Methylcholanthrene, a dioxin-like compound and also an inducer of cytochrome P4501A, can be used to construct animal models of leukemia. 3-Methylcholanthrene is a carcinogen used to induce transformation of cultured cells. It is also used to induce fibrosarcomas and skin carcinomas in laboratory animals. 3-methylcholanthrene is a potent aryl hydrocarbon receptor agonist. | ||
| M56339 | AHR antagonist 5 | Aryl hydrocarbon Receptor |
| AHR antagonist 5, a potent and orally active aryl hydrocarbon receptor (AHR) antagonist, has an IC50 of < 0.5 µΜ. | ||
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