Androgen receptor degrader-2 - Search Results

About 5 results found for searched term "Androgen receptor degrader-2" (0.417 seconds)

Cat.No.	Name	Target
M43587	Androgen receptor degrader-2	Androgen Receptor
	Androgen receptor degrader-2 is a potent androgen receptor degrader.
M29317	UT-34	Androgen Receptor
	UT-34 is a potent, selective and orally active second-generation pan-androgen receptor (AR) antagonist and degrader with IC50s of 211.7 nM, 262.4 nM and 215.7 nM for wild-type, F876L and W741L AR, respectively. UT-34 binds to ligand-binding domain (LBD) and function-1 (AF-1) domains and requires ubiquitin proteasome pathway to degrade the AR. UT-34 has anti-prostate cancer efficacy.
M29367	ARD-2128	PROTAC
	ARD-2128 is a highly potent, orally bioavailable PROTAC androgen receptor (AR) degrader. ARD-2128 effectively reduces AR protein, suppresses AR-regulated genes in tumor tissues, and inhibits growth of tumor without signs of toxicity. ARD-2128 has the potential for the research of the prostate cancer.
M57242	AZ'3137	Androgen Receptor
	AZ‘3137 is an orally active PROTAC-type androgen receptor (AR) degrader, with a DC50 value of 22 nM.
M58665	GDC-2992	PROTAC
	RO7656594
	GDC-2992 is an orally active androgen receptor (AR) degrader. GDC-2992 degrads AR with a DC50 value of 2.7 nM and inhibits proliferation with an IC50 valude of 9.7 nM in VCaPcells.