About 19 results found for searched term "Amidase" (0.127 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M42308 | Acid Ceramidase-IN-2 | Others |
| Acid Ceramidase-IN-2 is an acid ceramidase inhibitor with potentially antiproliferative and cytostatic activities. | ||
| M42358 | Amidase | Metabolite/Endogenous Metabolite |
| Amidases, a member of nitrilase superfamily, catalyzes the hydrolysis of an amide, leading to the formation of carboxylic acid and ammonia. | ||
| M56601 | Acid Ceramidase-IN-1 | Others |
| Acid Ceramidase-IN-1 is a potent and oral bioavailable acid ceramidase (AC, ASAH-1) inhibitor (hAC IC50=0.166 μM). | ||
| M58105 | Lysozyme (Recombinant) | Antibiotic |
| Muramidase | ||
| Lysozyme (EC 3.2.1.17) is an antimicrobial enzyme produced by animals that forms part of the innate immune system. | ||
| M2247 | Carmofur | DNA/RNA Synthesis |
| HCFU | ||
| Carmofur is a pyrimidine analog that is a prodrug of 5-fluorouracil (5-FU), which inhibits DNA Synthesis and has better antiproliferative activity than 5-FU. Carmofur is an inhibitor of Acidic Ceramidase (ASAH1) and a potential lead compound for non-cancer diseases such as Krabbe disease, acute lung injury (ALI), Parkinson's disease (PD), dementia, etc. Carmofur also has antifungal and antimicrobial properties. | ||
| M6074 | AA26-9 | Phospholipase |
| AA269 | ||
| AA26-9 is a potent and broad spectrum serine hydrolase inhibitor. AA26-9 targets included serine peptidases, lipases, amidases, esterases, and thioesterases. | ||
| M6578 | Ceranib 1 | Others |
| Ceranib 1 is a ceramidase inhibitor; antiproliferative. | ||
| M14512 | MAFP | Phospholipase |
| Methyl Arachidonyl Fluorophosphonate | ||
| MAFP (Methyl Arachidonyl Fluorophosphonate) is an selective, active-site directed and irreversible inhibitor of cPLA2 and iPLA2. MAFP is also a potent irreversible inhibitor of anandamide amidase. | ||
| M28429 | D-erythro-MAPP | Others |
| D-e-MAPP | ||
| D-erythro-MAPP (D-e-MAPP) is a ceramidase inhibitor, with an IC50 of 1-5 μM in vitro. | ||
| M28722 | ARN726 | Others |
| ARN726 is a potent NAAA (N-acylethanolamine acid amidase) inhibitor with an IC50 of 0.073 µM. ARN726 decreases alcohol self-administration in a dose-dependent manner. | ||
| M28771 | ARN14974 | Others |
| ARN14974, a benzoxazolone carboxamide, is a potent and systemically active inhibitors of intracellular acid ceramidase (IC50=79 nM). | ||
| M29984 | D-NMAPPD | GluR |
| (1R,2R)-B13 | ||
| D-NMAPPD ((1R,2R)-B13) is an acid ceramidase inhibitor. D-NMAPPD regulates NMDA receptor properties by enhancing endogenous production of ceramides. D-NMAPPD has anticancer effecs. | ||
| M42351 | Glucocerebrosidase | Metabolite/Endogenous Metabolite |
| Glucocerebrosidase (Glucosylceramidase; GBA) is a lysosomal enzyme that catalyzes the cleavage of β-glucosidic linkage of glucocerebroside (GC) into glucose and ceramide. | ||
| M55044 | Ceranib-2 | LPL Receptor |
| Ceranib-2 is a potent and nonlipid ceramidase inhibitor that inhibits cellular ceramidase activity with an IC50 of 28 μM in SKOV3 cells. Ceranib-2 decreases levels of sphingosine and S1P, induces cell apoptosis and exhibits anticancer activity. | ||
| M57025 | ARN19702 | Others |
| ARN19702 is a selective, orally active, reversible, and brain-penetrant N-acylethanolamine acid amidase (NAAA) inhibitor with an IC50 of 230 nM for human NAAA. | ||
| M56775 | LCL521 | Phospholipase |
| LCL521 is an acid ceramidase (ACDase) inhibitor. | ||
| M56767 | LCL521 dihydrochloride | Phospholipase |
| LCL521 dihydrochloride is an acid ceramidase (ACDase) inhibitor. | ||
| M56602 | SACLAC | Others |
| SACLAC, a Ceramide analog, is a potent and covalent acid ceramidase (ASAH1; AC) inhibitor with a Ki of 97.1 nM. | ||
| M58100 | Lysostaphin | Enzymes & Coenzymes |
| Lysostaphin is an antistaphylococcal agent. Lysostaphin has activities of three enzymes namely, glycylglycine endopeptidase, endo-β-N-acetyl glucosamidase and N-acteyl muramyl-L-alanine amidase. Lysostaphin specifically degrades bacteria such as Staphylococcus aureus whose cell wall has a glycine peptide bond structure, and achieves sterilisation by cleavage of its cell wall. | ||
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