About 3 results found for searched term "Alectinib" (0.132 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1942 | Alectinib | ALK |
| CH5424802; AF802 | ||
| Alectinib (CH5424802) is a highly selective, orally active and potent ALK inhibitor with IC50 of 1.9 nM. Alectinib (CH5424802) also inhibits ALK F1174L and ALK R1275Q with IC50s of 1 nM and 3.5 nM, respectively. Alectinib demonstrates effective central nervous system (CNS) penetration. | ||
| M4811 | CH5424802 HCl | ALK |
| AF802 HCl; Alectinib Hydrochloride | ||
| CH5424802 HCl is a potent ALK inhibitor with IC50 of 1.9 nM, sensitive to L1196M mutation. | ||
| M28756 | JH-VIII-157-02 | ALK |
| JH-VIII-157-02 is a structural analogue of alectinib, acts as an ALK inhibitor, and shows an IC50 of 2 nM for echinoderm microtubule-associated protein-like 4-ALK (EML4-ALK) G1202R in cells. | ||
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