About 27 results found for searched term "Aldose Reductase" (0.13 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M28233 | Caficrestat | Aldose Reductase |
| Aldose reductase-IN-1; AT-001 | ||
| Caficrestat (Aldose reductase-IN-1) is a inhibitor of aldose reductase with IC50 of 28.9 pM. | ||
| M4010 | Isoliquiritigenin | Aldose Reductase |
| GU17; ISL; Isoliquiritigen | ||
| Isoliquiritigenin is an anti-tumor flavonoid from the root of Glycyrrhiza glabra, which inhibits aldose reductase with an IC50 of 320 nM. | ||
| M4158 | Soyasaponin-Bb | Aldose Reductase |
| Soyasaponin Bb is a soybean saponin isolated from the legume family that acts asa differential inhibitor of aldose reductase (ARDI). | ||
| M4333 | Calceolarioside-B | Aldose Reductase |
| Calceolarioside B is a natural product isolated from the Stauntonia hexaphylla leaf. Calceolarioside B showed significant inhibitory activity against aldose reductase (RLAR) in rat lens with IC50 value of 23.99 μM. Calceolarioside B could effectively inhibit DPPH radical scavenging activity with IC50 value of 94.60 μM. | ||
| M4403 | Groenlandicine | Topoisomerase |
| Groenlandicine is a proto berberine alkaloid isolated from coptis chinensis. Groenlandicine has moderate inhibition of human recombinant aldose reductase (HRAR) with an IC50 value of 154.2 μM. Groenlandicine induces DNA cleavage mediated by topoisomerase I. | ||
| M4543 | Byakangelicin | Others |
| (Rac)-Byakangelicin is the racemate of Byakangelicin, which is mainly separated from the genus Angelica. Byakangelicin is an aldose reductase inhibitor with an IC50 value of 6.2 μM. | ||
| M4731 | Poliumoside | Aldose Reductase |
| Poliumoside, a coffee-acylated phenylpropane glycoside isolated from the stems and leaves of Brandisia hancei. Poliumoside inhibited the formation of advanced glycation end products (AGE) and rat lens aldose reductase (RLAR) with IC50 values of 19.69 and 8.47 μM, respectively. Poliumoside also has anti-inflammatory and antioxidant activities. | ||
| M5614 | Epalrestat | Others |
| ONO-2235 | ||
| Epalrestat is an aldose reductase inhibitor with IC50 of 72 nM. | ||
| M8057 | EBPC | Others |
| EBPC is an aldose reductase inhibitor; anti-cancer. | ||
| M8495 | Ranirestat | Others |
| AS-3201 | ||
| Ranirestat (AS-3201) is an aldose reductase (AR) inhibitor. | ||
| M8870 | Zopolrestat | Others |
| Zopolrestat is an inhibitor of Aldose Reductase. | ||
| M9725 | Ponalrestat | Aldose Reductase |
| MK-538; Statil | ||
| Ponalrestat is an orally active, selective and noncompetitive aldose reductase inhibitor. | ||
| M11063 | Ganoderic acid C2 | Aldose Reductase |
| Ganoderic acid C2 is a biologically active triterpenoid in Ganoderic acid C2 with potential anti-tumor biological activity, with antihistamine, anti-aging and cytotoxic effects. Ganoderic acid C2 has a high inhibitory activity against rat lens aldose reductase (RLAR), which IC50 The value is 3.8 μM. | ||
| M11067 | Ganoderic acid C6 | Aldose Reductase |
| Ganoderic acid C6 has inhibited aldose reductase activity. | ||
| M13426 | Danshenol B | Aldose Reductase |
| Danshenol B has aldose reductase (AR) inhibitory activity. | ||
| M14297 | Fidarestat | Others |
| SNK 860 | ||
| Fidarestat (SNK 860) is an inhibitor of aldose reductase, with IC50s of 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively; Fidarestat (SNK 860) has the potential to treat diabetic disease. | ||
| M18249 | Quercetin 3-gentiobioside | Aldose Reductase |
| Quercetin 3-gentiobioside is isolated from A. iwayomogi, AR and AGE formation inhibitor, demonstrates biological activities against Aldose reductase (AR) and the formation of advanced glycation endproducts (AGEs). | ||
| M20493 | 2-Chloro-1-(4-fluorobenzyl)benzimidazole | Others |
| 2-Chloro-1-(4-fluorobenzyl)benzimidazole is an aldose reductase (ALR2) inhibitor which is used for preparation of disubstituted benzimidazole derivative. | ||
| M20540 | Alrestatin | Others |
| Alrestatin is an inhibitor of aldose reductase which is involved in the pathogenesis of complications of diabetes mellitus, including diabetic neuropathy. | ||
| M21810 | Govorestat | Aldose Reductase |
| AT-007 | ||
| Govorestat (AT-007) is a central nervous system (CNS)-permeable aldose reductase inhibitor that prevents the conversion of glucose to sorbitol and may be used in studies related to neurological disorders. | ||
| M30830 | Imirestat | Aldose Reductase |
| AL 1576; Alcon 1576; HOE 843 | ||
| Imirestat (AL 1576) is an aldose reductase inhibitor, used for the treatment of diabetes. | ||
| M39051 | Hydroxyevodiamine | Aldose Reductase |
| Hydroxyevodiamine (Rhetsinine) inhibits aldose reductase with an IC50 value of 24.1 μM. | ||
| M39052 | Danshenol A | Aldose Reductase |
| Danshenol A is an aldose reductase (AR) inhibitor with an IC50 of 0.1 μM. Danshenol A can protect endothelial cells from oxidative stress by directly scavenging ROS. Danshenol A has anti-inflammatory and antitumor properties. | ||
| M42282 | Dehydroglyasperin D | Aldose Reductase |
| Dehydroglyasperin D inhibits rat and human Aldose Reductase (AR) (IC50: 62.4 μM and 176.2 μM respectively). | ||
| M42536 | PTP1B/AKR1B1-IN-1 | Phosphatase |
| PTP1B/AKR1B1-IN-1 is a dual inhibitor of protein tyrosine phosphatase 1B (PTP1B) and aldose reductase (AKR1B1), with IC50s of 0.06 μM and 4.3 μM, respectively. | ||
| M54848 | Bendazac L-Lysine | Others |
| Bendazac L-Lysine is an aldose reductase (AR) inhibitor, which can be used to inhibit the activity of AR in the eye to prevent cataracts. | ||
| M56589 | Tolrestat | Aldose Reductase |
| Tolrestat is a potent, orally active aldose reductase inhibitor with IC50 of 35 nM. | ||
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