About 24 results found for searched term "Adenosine receptor antagonist 1" (0.138 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M40660 | Adenosine receptor antagonist 1 | Adenosine Receptor |
| Adenosine receptor antagonist 1 is a selective adenosine receptor A2aR antagonist with an IC50 value of 0.29 nM and a 14-fold higher selectivity for A2aR than for A2bR. | ||
| M6920 | Lu AA 47070 | Others |
| Lu AA 47070 is a potent and selective precursor compound of adenosine A2A receptor antagonists with Ki values of 5.9, 260, 410 and <10,000 nM for A2A, A2B, A1 and A3 receptors, respectively. | ||
| M7915 | MRS 1191 | Adenosine Receptor |
| MRS1191 | ||
| MRS 1191 is putative A3 adenosine receptor antagonist, highly selective for human A3 receptor vs human A1 receptor. | ||
| M10191 | Vipadenant | Adenosine Receptor |
| BIIB014; CEB-4520 | ||
| Vipadenant, also known as BIIB014, CEB-4520, is a potent, selective and orally available adenosine A2A receptor antagonist with Ki of 1.3 nM. | ||
| M20627 | A2AR antagonist 1 | Adenosine Receptor |
| A2AR antagonist 1 is a potent A2AR (Adenosine A2A Receptor) antagonist with Ki values of 4 nM and 264 nM for A2AR and A1R, respectively. | ||
| M28033 | ST4206 | Adenosine Receptor |
| ST4206 is a potent and orally active adenosine A2A receptor antagonist, with Kis of 12 nM and 197 nM for adenosine A2A receptor and adenosine A1 receptor, respectively. ST4206 has the potential for Parkinson׳s disease research. | ||
| M28569 | PSB-1115 | Adenosine Receptor |
| PSB-1115 is a selective A2B Adenosine Receptor antagonist. PSB-1115 inhibits the 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced contraction inhibition of acetylcholine (ACh). | ||
| M29063 | Xanthine amine congener dihydrochloride | Adenosine Receptor |
| XAC dihydrochloride | ||
| Xanthine amine congener dihydrochloride (XAC dihydrochloride) is a potent Adenosine A1 receptor and A2 receptor antagonist with IC50 values of 1.8 and 114 nM, respectively. Xanthine amine congener acts as a convulsant agent in mice model. | ||
| M29697 | MRE3008F20 | Adenosine Receptor |
| MRE3008F20 is a highly efficient, highly selective and radioactive adenosine A3 receptor (AA3R) antagonist (Ki=1.8 nM). MRE3008F20 effectively antagonises Cl-IB-MECA-induced cAMP production in resting lymphocytes with an IC50 value of 5 nM. MRE3008F20 can be used in the study of AA3R. | ||
| M29942 | Tonapofylline | Adenosine Receptor |
| BG 9928 | ||
| Tonapofylline (BG 9928) is an orally active and selective adenosine A1 receptor antagonist with a Ki of 7.4 nM for human adenosine A1 receptor (hA1), which displays 915-fold selectivity versus human adenosine A2A receptor and 12-fold selectivity versus human adenosine A2B receptor and is used in development for the treatment of heart failure. | ||
| M30180 | ST 1535 | Adenosine Receptor |
| ST 1535 is a potent and orally active A2A adenosine receptor antagonist. ST 1535 shows antiparkinsonian activity and antitremorigenic effects. ST 1535 has the potential for the research of Parkinson’s disease. | ||
| M40651 | M1069 | Adenosine Receptor |
| M1069 is an orally active, potent, and selective adenosine receptor A2A/A2B antagonist, with more than 100-fold selectivity over A1 and A3 subtypes. In addition, M1069 is able to antagonize adenosine-induced immunosuppression and has antitumor activity, which can be used in solid tumor research. | ||
| M40652 | Adenosine receptor antagonist 2 | Adenosine Receptor |
| Adenosine receptor antagonist 2 is a potent, orally active and antitumor active adenosine receptor A2a/A2b antagonist with IC50 values of 1 nM and 3 nM, respectively. | ||
| M40653 | A2AR-antagonist-1 | Adenosine Receptor |
| A2AR-antagonist-1 is an orally active adenosine receptor A2AR antagonist with an IC50 value of 29 nM.A2AR-antagonist-1 is also a T-cell activator that acts by inhibiting immunosuppressive molecules (LAG-3 and TIM-3) and potentiating effector molecules (GZMB, IFNG and IL-2). It has antitumor activity and is metabolically stable in mouse liver microsomes. | ||
| M40654 | LAS38096 | Adenosine Receptor |
| LAS38096 is a potent, selective adenosine receptor A2B antagonist with a Ki value of 17 nM. | ||
| M40657 | A1AR antagonist 5 | Adenosine Receptor |
| A1AR antagonist 5 is a potent, selective adenosine receptor A1AR antagonist with a pIC50 of 5.83 and a pKi of 6.11.1. | ||
| M40658 | A1AR antagonist 4 | Adenosine Receptor |
| A1AR antagonist 4 is a potent, selective adenosine receptor A1AR antagonist with a pIC50 of 5.51 and a pKi of 6.29. | ||
| M40659 | hA2A/hCA XII modulator 1 | Adenosine Receptor |
| hA2A/hCA XII modulator 1 is a triazolopyrazine and a potent adenosine receptor hA2A antagonist, with Ki of 6.4 nM, 4.819 μM, and >30 μM for hA2AAR, hA1AR, and hA3AR, respectively. hA2A/hCA XII modulator 1 is a potent inhibitor of human carbonic anhydrase XII (hCA XII). In addition, hA2A/hCA XII modulator 1 is also a potent human carbonic anhydrase XII (hCA XII) inhibitor with Ki of 6.2 nM, 46 nM, 466 nM, 8.351 μM for hCA XII, hCA II, hCA IX, and hCA I, respectively, and can be used in cancer-related studies. | ||
| M40663 | A2A receptor antagonist 3 | Adenosine Receptor |
| A2A receptor antagonist 3 is an adenosine receptor A2a antagonist with a Ki of 0.4 nM. It binds to A2b, A1, and A3 receptors with Ki values of 37, 107, and 1467 nM, respectively. | ||
| M40665 | LJ-4517 | Adenosine Receptor |
| LJ-4517 is a potent adenosine receptor A2AAR antagonist with a Ki of 18.3 nM. | ||
| M41757 | PSB-1901 | Adenosine Receptor |
| PSB-1901 is a potent A2B adenosine receptor (A2BAR) antagonist with Kis of 0.0835 nM and 0.131 nM for human and mouse A2BARs respectively. | ||
| M41759 | Adenosine receptor antagonist 4 | Adenosine Receptor |
| Adenosine receptor antagonist 4 is an adenosine A1 receptor antagonist with a Ki of 101 nM for human A1 receptor. | ||
| M56113 | FK 453 | Adenosine Receptor |
| FK 453 is a potent and selective adenosine A1 receptor antagonist with an IC50 value of 17.2 nM. | ||
| M56106 | A2B receptor antagonist 2 | Adenosine Receptor |
| A2B receptor antagonist 2 is an adenosine receptor A2B antagonist, with Ki values of 2.30 μM, 6.8 μM and 3.44 μM for rA1, rA2A and hA2B, respectively. | ||
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