About 31 results found for searched term "Activated protein C" (0.098 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M14805 | Activated Protein C (390-404), human | Peptides |
| Activated Protein C (390-404), human is a peptide of the activated protein C (a vitamin K-dependent serine protease), potently inhibits APC anticoagulant activity. | ||
| M50313 | Activated protein C | Enzymes & Coenzymes |
| Activated protein C is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||
| M58110 | Recombinant Human RIPK3 Protein (E. coli, N-His) | Cytokines and Growth Factors |
| RIP-like protein kinase 3; RIP3 | ||
| RIPK3 is a kinase that controls necroptosis and apoptosis. In necroptosis, activated by TNF-α and ZBP1, RIPK3 phosphorylates MLKL, leading to membrane damage. Necroptosis is dependent on receptor-interacting protein kinase 3 (RIPK3), a protein shown to play an important role in experimental models of critical illness. RIPK3 promotes kidney tubular injury via mitochondrial dysfunction. The FAO-dependent RIPK3 mediates pathogenesis of acute lung injury. | ||
| M1822 | PD98059 | MEK |
| PD 98059; PD‐98059 | ||
| PD98059 is a potent and selective inhibitor of mitogen-activated protein kinase kinase (MKK / MEK) with IC50 value of 2-7 μM. The expression of KAT2B protein in cells is significantly decreased after PD98059 inhibits ERK signaling pathway. | ||
| M2238 | Dorsomorphin dihydrochloride | AMPK |
| BML-275 2HCl; Compound C 2HCl | ||
| Dorsomorphin (BML-275; Compound C) dihydrochloride is a potent inhibitor of AMP-activated protein kinase (AMPK), with a Ki of 109 nM. Dorsomorphin dihydrochloride inhibits BMP pathway by targeting the type I receptors ALK2, ALK3, and ALK6. Dorsomorphin dihydrochloride induces autophagy. | ||
| M2450 | Bergapten | Autophagy |
| 5-Methoxypsoralen | ||
| Bergapten is a psoralen that can be photoactivated and is capable of crossing-linking DNA, covalently modifying proteins and lipids, and consequently inhibiting cell replication. | ||
| M8129 | RN-1747 | Others |
| TRPV4, a close relative of the vanilloid receptor TRPV1, is activated by diverse modalities such as endogenous lipid ligands, hypotonicity, protein kinases and, possibly, mechanical inputs. | ||
| M8200 | SB 220025 trihydrochloride | Others |
| SB 220025 is a potent, specific inhibitor of human p38 mitogen-activated protein (MAP) kinase, with an IC50 value of 60 nM and 50- to 1000-fold selectivity. | ||
| M8728 | ESI-05 | Transferase |
| NSC 116966 | ||
| Esi-05 (NSC 116966) is a camp-specific direct activated exchange protein 2 (EPAC2) antagonist with an IC50 value of 0.4 µM that inhibits camp-induced EPAC2 activation and EAPC2-mediated Rap1 activation. | ||
| M8910 | Pamapimod | p38 MAPK |
| R-1503, Ro4402257 | ||
| Pamapimod is a novel p38 mitogen-activated protein kinase inhibitor, inhibited p38alpha and p38beta enzymatic activity, with IC50 values of 0.014 +/- 0.002 and 0.48 +/- 0.04 microM, respectively. | ||
| M9121 | LY303511 hydrochloride | mTOR |
| NV-128; EM 101 hydrochloride | ||
| LY303511 hydrochloride is a structural analogue of LY294002. LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells via hydrogen peroxide-mediated mitogen-activated protein kinase activation and up-regulation of death receptors. | ||
| M9160 | BMS-582949 | p38 MAPK |
| PS540446; BMS582949 free base | ||
| BMS-582949 is a potent and selective P38 mitogen-activated protein kinase (P38 MAPK) inhibitor with IC50 of 13nM. | ||
| M9865 | Recombinant mouse IFN-γ (E. coli) | Cytokines and Growth Factors |
| IFN gamma | ||
| Recombinant mouse IFN-γ (Murine IFN-γ) （E. coli）is an unstable interferon produced by CD4 and CD8 T lymphocytes and activated NK cells. IFN-γ receptors are present in most immune cells, and they respond to IFN-γ signaling by increasing the surface expression of class I γ proteins. ED50 < 0.15 ng/ml, measured by cytotoxicity assay using WEHI-279 cells. | ||
| M13400 | Recombinant Human UBA5 (E.coli, N-6His) | Cytokines and Growth Factors |
| Ubiquitin-like modifier-activating enzyme 5 | ||
| UBA5 is a member of the ubiquitin activated E1 family and UBA5 subfamily. Ubiquitin and ubiquitin-like proteins are identified as covalently binding to a variety of cellular substrates through a three-step enzymatic pathway. Ubiquitin activase (E1) plays a crucial role in the first step of activating ubiquitin or ubiquitin-like proteins in the ubiquitination pathway. | ||
| M13739 | OTS964 hydrochloride | TOPK/PBK |
| OTS964 hydrochloride is an orally active, high affinity and selective TOPK (T-lymphokine-activated killer cell-originated protein kinase) inhibitor with an IC50 of 28 nM. | ||
| M13807 | Ampkinone | AMPK |
| Ampkinone is an indirect AMP-activated protein kinase (AMPK) activator. | ||
| M15016 | Recombinant Human Eotaxin-2/CCL24 (E. coli) | Cytokines and Growth Factors |
| C-C motif chemokine 24; CK-beta-6 | ||
| Recombinant human Eotaxin-2/CCL24 protein (E. coli) is a new CC chemokine recently discovered. It is produced by activated monocytes and T lymphocytes. Protein structure: CCL24 (VAL27-ALA104), Accession # : O00175. | ||
| M19445 | Kahweol | AMPK |
| Kahweol inhibits adipogenesis and increase glucose uptake by AMP-activated protein kinase (AMPK) activation. Kahweol induces apoptosis. | ||
| M20111 | WAY-325490 | Others |
| WAY-325490 is a mitogen activated protein kinase-activated protein kinase-2 inhibitor | ||
| M20176 | WAY-382818 | Others |
| WAY-382818 has mitogen-activated protein kinase phosphatase-1 inhibitory activity. | ||
| M20713 | DMX-5084 | MAPKAPK2/MAP3K/MAP4K |
| DMX-5804 is a potent, orally active and selective inhibitor of Mitogen-activated protein kinase kinase kinase kinase-4 (MAP4K4) with IC50 of 3 nM for human MAP4K4. DMX-5804 is more potent on human MAP4K4 with pIC50 of 8.55 than MINK1/MAP4K6 and TNIK/MAP4K7 with pIC50 of 8.18 and 7.96, respectively. | ||
| M20734 | (E/Z)-BCI | Phosphatase |
| BCI, NSC 150117 | ||
| (E/Z)-BCI (BCI, NSC 150117) is an inhibitor of dual specific phosphatase 1/6 (DUSP1/DUSP6) and mitogen-activated protein kinase with EC50 of 13.3 μM and 8.0 μM for DUSP6 and DUSP1 in cells, respectively. (E)-BCI induces apoptosis via generation of reactive oxygen species (ROS) and activation of intrinsic mitochondrial pathway in H1299 lung cancer cells. | ||
| M21203 | Recombinant Human/Mouse/Rat Irisin (HEK293, C-6His) | Cytokines and Growth Factors |
| Fibronectin type III domain-containing protein 5 | ||
| Fibronectin type III domain-containing protein 5 is the precursor of irisin. Mature human, mouse share 100% sequence identity.Irisin induces expression of peroxisome proliferatoractivated receptor γ coactivator 1α (PGC1α) and uncoupling protein1(UCP1), mitochondrialassociated metabolic proteins. Irisin induces the transition of white adipose tissue into more metabolically active beige adipose tissue.Irisin also regulates neuronal cell differentiation and neurite outgrowth in the brain and is involved in the differentiation of osteoblasts. | ||
| M21204 | Recombinant Human/Mouse/Rat Irisin (HEK293, C-Fc) | Cytokines and Growth Factors |
| Fibronectin type III domain-containing protein 5 | ||
| Fibronectin type III domain-containing protein 5 is the precursor of irisin. Mature human, mouse share 100% sequence identity.Irisin induces expression of peroxisome proliferatoractivated receptor γ coactivator 1α (PGC1α) and uncoupling protein1(UCP1), mitochondrialassociated metabolic proteins. Irisin induces the transition of white adipose tissue into more metabolically active beige adipose tissue.Irisin also regulates neuronal cell differentiation and neurite outgrowth in the brain and is involved in the differentiation of osteoblasts. | ||
| M21205 | Recombinant Human/Mouse/Rat Irisin (HEK293, N-6His) | Cytokines and Growth Factors |
| Fibronectin type III domain-containing protein 5 | ||
| Fibronectin type III domain-containing protein 5 is the precursor of irisin. Mature human, mouse share 100% sequence identity.Irisin induces expression of peroxisome proliferatoractivated receptor γ coactivator 1α (PGC1α) and uncoupling protein1(UCP1), mitochondrialassociated metabolic proteins. Irisin induces the transition of white adipose tissue into more metabolically active beige adipose tissue.Irisin also regulates neuronal cell differentiation and neurite outgrowth in the brain and is involved in the differentiation of osteoblasts. | ||
| M21660 | MMI-0100 | Others |
| MMI-0100 is a novel cell permeant peptide inhibitor of Mitogen Activated Protein Kinase Activated Protein Kinase II (MK2), MMI-0100 suppresses IL-6 expression without effect on IL-8 expression. MMI-0100 suppresses fibrotic processes such as vein graft disease. | ||
| M25290 | Topsalysin | Others |
| PRX-302; PRX302 PSA-PAH1 | ||
| Topsalysin (PRX-302; PRX302; PSA-PAH1) is a PSA-activated protoxin, a pore-forming protein (synthetic proaerolysin) fusion protein with human prostate-specific antigen. Topsalysin has tumor suppression effect in mice modle. | ||
| M25459 | Zunsemetinib | p38 MAPK |
| ATI-450; CDD-450 | ||
| Zunsemetinib (CDD-450) is an orally active and selective p38α mitogen-activated protein kinase-activated protein kinase 2 (MK2) pathway inhibitor. | ||
| M27772 | D-Lys(Z)-Pro-Arg-pNA | Fluorescent Dye |
| Chromozym Pca | ||
| D-Lys(Z)-Pro-Arg-pNA (Chromozym Pca) is a luminescent substrate of activated protein C (APC). | ||
| M28166 | PKR-IN-C51 | Serine/Threonine Protease |
| PKR-IN-C51(compound 51) is an ATP-competitive double-stranded RNA-activated protein kinase (PKR) inhibitor with an IC50 of 9 μM. PKR-IN-C51 inhibits intracellular PKR activation in a dose-dependent manner in primary mouse macrophages. | ||
| M29905 | FgGpmk1-IN-1 | Others |
| FgGpmk1-IN-1 is a novel fusarium graminearum mitogen-activated protein kinase (FgGpmk1) inhibitor with an EC50 value of 3.46 μg/mL. | ||
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