AR antagonist 1 hydrochloride - Search Results

About 4 results found for searched term "AR antagonist 1 hydrochloride" (0.279 seconds)

Cat.No.	Name	Target
M43417	AR antagonist 1 hydrochloride	Ligand for E3 Ligase
	AR antagonist 1 hydrochloride is a potent androgen receptor (AR) antagonist and binds to E3 ligase ligands with weak binding affinities to VHL protein in the synthesis of PROTAC ARD-266.
M7590	A3 hydrochloride	PKA
	A-3 hydrochloride
	A-3 Hydrochloride is A potent, cellular permeable, reversible, atP-competitive, non-selective antagonist targeting multiple kinases. A-3 Hydrochloride is an inhibitor of PKA (Ki=4.3 µM), casein kinase II (Ki=5.1 µM), and myosin light chain kinase (MLCK) (Ki=7.4 µM). A-3 hydrochloride also inhibited PKC and casein kinase I activity with Ki of 47 µM and 80 µM, respectively.
M25555	BIIE-0246 hydrochloride	Neuropeptide Receptor
	AR-H 053591 hydrochloride
	BIIE-0246 hydrochloride (AR-H 053591 hydrochloride) is a potent and selective NPY2R (neuropeptide Y receptor 2) antagonist with an IC50 value of 15 nM for rat [125I]PYY3-36. BIIE-0246 hydrochloride decreases the expression of p-AKT S473, P-p44/42 MAPK under the NPY-stimulated. BIIE-0246 hydrochloride reduces albuminuria in ADR nephropathy.
M59054	ENMD-1068 hydrochloride	PAR
	ENMD1068 HCl
	ENMD-1068 hydrochloride is a selective protease-activated receptor 2 (PAR2) antagonist. ENMD-1068 hydrochloride reduces hepatic stellate cell activation and collagen expression by inhibiting TGF-β1/Smad signaling.