About 5 results found for searched term "AM966" (0.125 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2144 | Topotecan hydrochloride | Topoisomerase |
| Hycamtin; NSC 609669; SKF 104864A hydrochloride | ||
| Topotecan hydrochloride is a topoisomerase I inhibitor and an apoptosis inducer. | ||
| M8992 | AM966 | LPL Receptor |
| AM966 is a potent, selective and orally active LPA(1) receptor antagonist which inhibits lung fibrosis in the mouse bleomycin model. | ||
| M20630 | ex229 (compound 991) | AMPK |
| EX229 (compound 991) is a potent AMPK activator that is 5-10-fold more potent than A769662 in activating AMPK. | ||
| M28491 | MRT199665 | Salt-inducible Kinase |
| MRT199665 is a potent and ATP-competitive, selective MARK/SIK/AMPK inhibitor with IC50s of 2/2/3/2 nM, 10/10 nM, and 110/12/43 nM for MARK1/MARK2/MARK3/MARK14, AMPKα1/AMPKα2, and SIK1/SIK2/SIK3, respectively. MRT199665 causes apoptosis in MEF2C-activated human acute myeloid leukemias (AML) cells. MRT199665 inhibits the phosphorylation of SIK substrate CRTC3 at S370. | ||
| M29103 | VU6001966 | GluR |
| VU6001966 (compound 15m) is a potent and cross the blood-brain barrier mGlu2 (metabotropic glutamate receptor 2) negative allosteric modulator with IC50s of 78 nM and >30 µM for mGlu2 and mGlu3, respectively. VU6001966 can serve as an mGlu2 PET tracer. | ||
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