About 13 results found for searched term "AG-270" (0.157 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M10762 | AG-270 | Methionine Adenosyltransferase |
| AG-270 is a non-competitive, first-of-its-kind, reversible, orally active MAT2A allogeneic inhibitor IC50 The value is 14 nM. | ||
| M3222 | Peramivir Trihydrate | Anti-infection |
| BCX-1812 Trihydrate; RWJ-270201 Trihydrate; S-021812 Trihydrate | ||
| Peramivir Trihydrate is a trihydrate of the anti-infection agent peramivir (RWJ-270201,BCX-1812) which is a transition-state analogue and a potent, specific influenza viral neuraminidase inhibitor with an IC50 of median 0.09 nM. | ||
| M11227 | FM-479 | JAK |
| Fm-479 was a negative control of FM-381 and showed no activity against JAK3 or other kinases. Fm-381 is a potent covalent reversible inhibitor of JAK3 targeting unique Cys909. For JAK3, FM-381 was 410, 2700 and 3600 times more selective than JAK1, JAK2 and TYK2 with IC50 of 127 pM. | ||
| M10515 | JNJ-10229570 | Melanocortin Receptor |
| UNII-N9IX402L35; JNJ10229570 | ||
| JNJ-10229570 (UNII-N9IX402L35) is is a novel MC1R and MC5R antagonist, which inhibits the binding of 125I-NDP-α-MSH to cells expressing human MC1R and MC5R with IC50 values of 270 nM and 200 nM, respectively. | ||
| M11167 | A-381393 | Dopamine Receptor |
| A-381393 IS AN EFFECTIVE, SELECTIVE, AND BLOOD-BRAIN BARRIER-PERMEABLE dopamine D4 receptor Antagonist, dopamine D for humans4.4，D4.2 AND D4.7 receptors Ki The values are 1.5, 1.9, and 1.6 nM, respectively, with selectivity being D1，D2，D3，D5 MORE THAN 2700 TIMES THE DOPAMINE RECEPTOR. A-381393 VS. 5-HT2A MODERATE SELECTIVITY, Ki The value is 370 nM. | ||
| M14231 | PEAQX tetrasodium hydrate | GluR |
| NVP-AAM077 tetrasodium hydrate | ||
| PEAQX (NVP-AAM077) tetrasodium hydrate is a potent, selective and orally active NMDA antagonist, with IC50 values of 270 nM and 29600 nM for hNMDAR 1A/2B and hNMDAR 1A/2B, respectively. | ||
| M28421 | (S)-UFR2709 | AChR/AChE |
| (S)-UFR2709 is a competitive nAChR antagonist and displays higher affinity for α4β2 nAChRs than for α7 nAChRs. (S)-UFR2709 decreases anxiety and reduces ethanol consumption and ethanol preference in alcohol-preferring rats. (S)-UFR2709 acts as an anxiolytic agent and can be used for the study of nicotine addiction. | ||
| M29439 | NVS-PAK1-C | PAK |
| NVS-PAK1-C is a potent, ATP-competitive and specific allosteric PAK1 inhibitor probe with IC50 values of 5 nM and 6 nM for dephosphorylated PAK1 and phosphorylated PAK1, respectively. NVS-PAK1-C is also against dephosphorylated PAK2 (IC50=270 nM) and phosphorylated PAK2 (IC50=720 nM). | ||
| M29610 | NBD-14270 | HIV Protease |
| NBD-14270, a pyridine analogue, is a potent HIV-1 entry antagonist with an IC50 of 180 nM against 50 HIV-1 Env-pseudotyped viruses. NBD-14270 binds to HIV-1 gp120 and shows potent antiviral activity. NBD-14270 shows low cytotoxicity (CC50>100 μM). | ||
| M30697 | EMD527040 | Integrin |
| EMD527040 is a potent and highly selective αvβ6 antagonist with antifibrotic activities. EMD527040 can be used for carcinoma and liver fibrosis research. | ||
| M31049 | (S)-UFR2709 hydrochloride | AChR/AChE |
| (S)-UFR2709 (hydrochloride) is a competitive nAChR antagonist and displays higher affinity for α4β2 nAChRs than for α7 nAChRs. (S)-UFR2709 (hydrochloride) decreases anxiety and reduces ethanol consumption and ethanol preference in alcohol-preferring rats. (S)-UFR2709 (hydrochloride) acts as an anxiolytic agent and can be used for the study of nicotine addiction. | ||
| M56107 | Binodenoson | Adenosine Receptor |
| Binodenoson (MRE-0470) is a potent and selective A2A adenosine receptor agonist (KD=270 nM). | ||
| M55886 | PEAQX | Caspase |
| PEAQX (NVP-AAM077) is an orally active and selective NMDA antagonist, with IC50 values of 270 nM and 29.6 μM for hNMDAR 1A/2A and hNMDAR 1A/2B, respectively. | ||
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