About 12 results found for searched term "A37" (0.187 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M6384 | A37 | ALDH |
| A37 is a aLDH1A1 inhibitor. | ||
| M40682 | RA375 | Proteasome |
| RA375 is an inhibitor of the 26S proteasome subunit RPN13. It can activate UPR signaling, generate ROS and activate apoptosis in cancer cells, and its anti-tumor activity is 10 times higher than that of RA190. | ||
| M1949 | Onalespib (AT13387) | HSP |
| AT-13387; Onalespib | ||
| Onalespib (AT13387) is a novel, high-affinity heat-shock protein 90 (HSP90) inhibitor with IC50 of 18 nM in A375 cells. | ||
| M4288 | Atractylenolide I | TLR |
| Atractylenolide I is a sesquiterpene obtained from the roots of Atractylenolide. Atractylenolide I has neuroprotective, anti-allergic, anti-inflammatory and anticancer activities. Atractylenolide I is an antagonist of TLR4 and can also reduce the phosphorylation of JAK2 and STAT3 in A375 cells. | ||
| M6796 | HLM006474 | E2F (Early 2 Factor) |
| HLM-006474 | ||
| HLM006474 is a pan E2F inhibitor, which inhibits E2F4 DNA-binding with an IC50 of 29.8 µM in A375 cells. | ||
| M8758 | GW806742X | Necroptosis |
| GW806742X is an ATP site-targeing kinase inhibitor (IC50 in nM = 2/VEGFR2, 15/SRC, 47/C-FMS, 851/GSK3, 9016/ERBB2, 9120/FGFR) with potent antiproliferation activity against cancer cultures (IC50 in nM = 5/HUVEC-v, 424/HUVEC-b, 81/HEF, 453/MDA468, 470/A375P, 693/HT29, 734/PC3), GW806742X is now better known as Compound 1 for its anti-necroptosis activity via affinity interaction with ML | ||
| M9492 | B-Raf inhibitor 1 | Raf |
| ABM-0403 | ||
| B-Raf inhibitor 1 is a potent and selective B-Raf inhibitor with cell IC50s of 0.31 µM and 2 nM for A375 proliferation and A375 p-ERK, respectively. | ||
| M13642 | CX-5461 dihydrochloride | DNA/RNA Synthesis |
| CX-5461 dihydrochloride is a potent and orally bioavailable inhibitor of Pol I-mediated rRNA synthesis, with IC50s of 142 nM in HCT-116, 113 nM in A375, and 54 nM in MIA PaCa-2 cells, and shows little or no effect on Pol II (IC50 ≥25 μM). | ||
| M14169 | GDC-0623 | MEK |
| RG 7421; MEK inhibitor 1 | ||
| GDC-0623 (RG 7421) is a potent, ATP-uncompetitive inhibitor of MEK1 (Ki=0.13 nM, +ATP), and displays 6-fold weaker potency against HCT116 (KRAS (G13D), EC50=42 nM) versus A375 (BRAFV600E, EC50=7 nM). | ||
| M16449 | Harringtonolide | FAK |
| Harringtonolide is a potent RACK1 inhibitor (IC50=39.66 μM in A375 cells). Harringtonolide inhibits the epithelial-mesenchymal transition (EMT) process and cell proliferation by affecting the interaction between FAK and RACK1. | ||
| M30026 | UC-112 | IAP |
| UC-112 is a novel potent IAP(Inhibitor of apoptosis) inhibitor. UC-112 potently inhibit cell growth in two human melanoma (A375 and M14) and two human prostate (PC-3 and DU145) cancer cell lines(IC50=0.7-3.4 uM). | ||
| M42974 | Benzyl DC-81 | Others |
| Benzyl DC-81 is an anticancer agent with antiproliferative activity against A375 and MCF-7 cells. | ||
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
