About 11 results found for searched term "99-14-9" (0.119 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M7533 | SHP099 hydrochloride | Phosphatase |
| SHP099 HCl; CAS# 2200214-93-1 | ||
| SHP099 hydrochloride is a potent, selective, orally available SHP2 inhibitor with an IC50 of 70 nM. | ||
| M16794 | Vicenin-3 | Flavonoids |
| Vicenin-3 | ||
| M20565 | Tricarballylic acid | Others |
| Carballylic acid; 1,2,3-Propanetricarboxylic acid; β-Carboxyglutaric acid; Propane-1,2,3-tricarboxylic acid | ||
| Tricarballylic acid is an inhibitor of aconitase and therefore interferes with the Krebs cycle. | ||
| M30987 | ZZL-7 | Serotonin Transporter |
| ZZL-7 is a fast-onset antidepressant agent. ZZL-7 works by disrupting the interaction between the serotonin transporter (SERT) and neuronal nitric oxide synthase (nNOS) in the dorsal raphe nucleus (DRN). ZZL-7 can cross the blood-brain barrier readily. ZZL-7 can be used for the research of major depressive disorder (MDD). | ||
| M5307 | Afatinib dimaleate | EGFR/HER2 |
| BIBW 2992MA2; BIBW2992; Afatinib | ||
| Afatinib (BIBW2992) Dimaleate irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively; 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant. | ||
| M21035 | LCH-7749944 | PAK |
| GNF-PF-2356 | ||
| LCH-7749944 (GNF-PF-2356) is a novel and potent p21-activated kinase 4 (PAK4) inhibitor with an IC50 of 14.93 μM and has less potently inhibitory effect against PAK1, PAK5 and PAK6. LCH-7749944 causes successful inhibition of EGFR activity due to its inhibitory effect on PAK4. | ||
| M27718 | AUTEN-99 hydrobromide | Others |
| Autophagy enhancer-99 hydrobromide | ||
| AUTEN-99 (hydrobromide) is a novel inhibitor of the myotubularin phosphatase Jumpy (also called MTMR14). AUTEN-99 (hydrobromide) crosses the blood-brain barrier and exerts potent neuroprotective effects. | ||
| M28491 | MRT199665 | Salt-inducible Kinase |
| MRT199665 is a potent and ATP-competitive, selective MARK/SIK/AMPK inhibitor with IC50s of 2/2/3/2 nM, 10/10 nM, and 110/12/43 nM for MARK1/MARK2/MARK3/MARK14, AMPKα1/AMPKα2, and SIK1/SIK2/SIK3, respectively. MRT199665 causes apoptosis in MEF2C-activated human acute myeloid leukemias (AML) cells. MRT199665 inhibits the phosphorylation of SIK substrate CRTC3 at S370. | ||
| M28726 | GSK3368715 | Histone Methyltransferase |
| EPZ019997 | ||
| GSK3368715 (EPZ019997) is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50=3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8)). GSK3368715 (EPZ019997) produces a shift in arginine methylation states, alters exon usage, and has strong anti-cancer activity. | ||
| M29986 | MAGL-IN-5 | MAGL |
| CAY10499 | ||
| MAGL-IN-5 (CAY10499) is a non-selective lipase inhibitor with IC50 values of 144, 90, and 14 nM for human recombinant monoacylglycerol lipase(MAGL),hormone sensitive lipase(HSL), and fatty acid amide hydrolase(FAAH) respectively. | ||
| M30161 | UC-857993 | Ras |
| UC-857993 is a selective SOS1-Ras inhibitor (Kd=14.7 μM, His6-SOS1cat), suppressing catalytic activity. UC-857993 also inhibits ERK and Ras activation, suppresses the growth of mouse embryonic fibroblasts (MEFs). | ||
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