About 9 results found for searched term "886-50-0" (0.127 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M6002 | Terbutryn | Others |
| Terbutryn is a selective herbicide and a triazine compound. It is absorbed by the roots and foliage and acts as an inhibitor of photosynthesis. | ||
| M1661 | AZD6244 | MEK |
| Selumetinib, ARRY-142886 | ||
| AZD6244 (ARRY-142886, Selumetinib) is a potent MEK 1/2 inhibitor with GI50 values ranging from 14 to 50 nM. | ||
| M1987 | LY2886721 | BACE |
| LY2886721 is an effective, selective, orally active inhibitor of beta-site amyloid precursor protein lyase 1 (BACE1) with an IC50 of 20.3 nM against recombinant human BACE1. LY2886721 showed higher selectivity for BACE1 than cathepsin D, pepsin and renin, but lacked selectivity for BACE2 (IC50 was 10.2 nM). LY2886721 crosses the blood-brain barrier and can be used to study Alzheimer's disease. | ||
| M3728 | MK 886 | Lipoxygenase |
| L-663536 | ||
| Mk-886 (L 663536) is a potent, cellular permeable, orally active inhibitor of FLAP (IC50 at 30 nM) and leukotriene biosynthesis (IC50 at 3 nM and 1.1μM in whole white blood cells and human whole blood, respectively). Mk-886 is also a non-competitive PPARα antagonist that can induce apoptosis. | ||
| M9957 | Finerenone | Mineralocorticoid Receptor |
| BAY94-8862 | ||
| Finerenone (BAY 94-8862) is a third generation selective, oral active, non-steroidal halocorticoid receptor (MR) antagonist (IC50=18 nM). Finerenone showed good selectivity (>500-fold) compared to glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (AR). Finerenone has potential applications in the study of heart and kidney diseases, such as type 2 diabetes and chronic kidney disease. | ||
| M13686 | MKC8866 | IRE1 |
| MKC8866, a salicylaldehyde analog, is a potent, selective IRE1 RNase inhibitor with an IC50 of 0.29 μM in human vitro. | ||
| M29234 | GNE-886 | Epigenetic Reader Domain |
| GNE-886 (Compound 21) is a potent and selective inhibitor of Cat eye syndrome chromosome region candidate 2 bromodomain (CECR2) (BRD) with an IC50 value of 0.016 µM and an EC50 value of 370 nM. GNE-886 also inhibits BRD9 with an IC50 value of 1.6 µM. | ||
| M41477 | MK-886 sodium salt | Others |
| MK-886 (L 663536) sodium salt is a potent, cell-permeable and orally active FLAP (IC50 of 30 nM) and leukotriene biosynthesis inhibitor. | ||
| M42632 | LY2886721 hydrochloride | Gamma-secretase/Beta-secretase |
| LY2886721 hydrochloride is a potent, selective and orally active beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 20.3 nM for recombinant human BACE1. | ||
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