About 11 results found for searched term "67-71-0" (0.126 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M14387 | Dimethyl sulfone | Metabolite/Endogenous Metabolite |
| Dimethyl sulfone is an endogenous metabolite. | ||
| M29855 | dCeMM2 | PROTAC |
| dCeMM2 (Compound 2) is a glue degrader. dCeMM2 induces ubiquitination and degradation of cyclin K by prompting an interaction of CDK12-cyclin K with a CRL4B ligase complex. | ||
| M51969 | 3, 5-Diiodo-D-tyrosine | Amino Acid Derivatives |
| 3,5-Diiodo-D-tyrosine is a tyrosine derivative. | ||
| M56101 | RS 39604 | 5-HT Receptor |
| RS 39604 is a potent, selective, and orally active 5-HT4 receptor antagonist with a pKi of 9.1 in guinea pig striatal membranes. | ||
| M2050 | GSK2636771 | PI3K |
| GSK2636771 is a potent, orally available and specific PI3K p110β (PI3K beta, PI3Kβ) inhibitor. | ||
| M2271 | PF-4708671 | S6 Kinase |
| PF-04708671 | ||
| PF-4708671 is a novel cell-permeable inhibitor of S6K1 with Ki/IC50 value of 20 nM/160 nM. PF4708671 inhibits MSK1 (IC50 of 0.95 μM) 4-fold more weakly than S6K1. | ||
| M20981 | BI-671800 | Prostaglandin Receptor |
| AP-761, Cmpd A | ||
| BI-671800 (AP-761, Cmpd A) is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2) with IC50 of 4.5 nM and 3.7 nM for PGD2 binding to human CRTH2 and murine CRTH2, respectively. BI-671800 is associated with a small improvement in FEV1 in symptomatic controller-naïve asthma patients, and in patients on ICS. | ||
| M28479 | VU0467485 | AChR/AChE |
| AZ13713945 | ||
| VU0467485 (AZ13713945) is a potent, selective, and orally bioavailable muscarinic acetylcholine receptor 4 (M4) positive allosteric modulator (PAM). VU0467485 (AZ13713945) potentiates activity of ACh at M4 with EC50s of 26.6 nM and 78.8 nM at rat and human M4 receptors, respectively. VU0467485 (AZ13713945) shows selectivity for M4 over human and rat M1/2/3/5. VU0467485 (AZ13713945) displays moderate to high CNS penetration. VU0467485 (AZ13713945) has antipsychotic-like activity. | ||
| M28634 | PF-06648671 | Gamma-secretase/Beta-secretase |
| PF-06648671 is a novel, brain-penetrable, and orally active γ-secretase modulator (GSM). PF-06648671 reduces Aβ42 and Aβ40, with concomitant increases in Aβ37 and Aβ38 in vitro. PF-06648671 is used for the study of Alzheimer’s disease. | ||
| M29167 | PF-06795071 | MAGL |
| PF-06795071 is a potent and selective covalent MAGL inhibitor with an IC50 of 3 nM. | ||
| M52427 | β-Secretase inhibitor | Gamma-secretase/Beta-secretase |
| β-Secretase inhibitor ([Asn670, Sta671, Val672]-Amyloid β Peptide (662-675)) is a β-secretase and BACE1 inhibitor (IC50: 25 nM for β-secretase). | ||
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