About 9 results found for searched term "57-37-4" (0.131 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M20416 | Benactyzine hydrochloride | AChR/AChE |
| Benactyzine hydrochloride is a centrally acting muscarinic antagonist. It is used as an antidepressant in the treatment of depression and associated anxiety. | ||
| M21640 | Tinlorafenib | Raf |
| PF-07284890; ARRY-461 | ||
| Tinlorafenib (PF-07284890) is an orally active BRAF kinase inhibitor, with IC50 values of 4.25 and 2.7 nM for BRAFV600E/V600K respectively. | ||
| M28610 | TAK1-IN-4 | p38 MAPK |
| TAK1-IN-4 (Compound 14) is a TAK1 inhibitor. | ||
| M42153 | B-Raf IN 13 | Raf |
| B-Raf IN 13 is a BRAF inhibitor with an IC50 of 3.55 nM in BRAF V600E enzyme assay. | ||
| M2869 | MRS 2578 | P2 Receptor |
| MRS2578 is a potent P2Y6 receptor antagonist with IC50 of 37 nM, exhibits insignificant activity at P2Y1, P2Y2, P2Y4,and P2Y11 receptors. | ||
| M10129 | CCT245737 | Checkpoint |
| SRA737; PNT-737 | ||
| CCT245737 is a potent, selective and orally active checkpoint kinase 1 (CHK1) inhibitor, with IC50 values of 1.3 nM, 2440 nM and 30 nM for CHK1, CHK2 and G2 check point abrogation, respectively. | ||
| M10958 | JNJ-63576253 | Androgen Receptor |
| TRC-253 | ||
| JNJ-63576253 (TRC-253) is a potent and orally active complete antagonist of the androgen receptor against F877L mutant AR and wild-type AR in LNCaP cells IC50 The values are 37 and 54 nM, respectively. JNJ-63576253 can be used in the study of castration-resistant prostate cancer (CRPC). | ||
| M29113 | GNE 5729 | GluR |
| GNE 5729 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 37 nM for GluN2A, 4.7 and 9.5 μM for GluN2C and GluN2D, respectively. | ||
| M29251 | JNJ-63576253 free base | Androgen Receptor |
| TRC-253 free base | ||
| JNJ-63576253 (TRC-253) free base is a potent and orally active full antagonist of androgen receptor (AR), with IC50s of 37 and 54 nM for F877L mutant AR and wild-type AR in LNCaP cells. JNJ-63576253 free base can be used for the research of castration-resistant prostate cancer (CRPC). | ||
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