About 12 results found for searched term "51-60-5" (0.123 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M5477 | Carbazochrome sodium sulfonate (AC-17) | Adrenergic Receptor |
| AC-17 | ||
| Carbazochrome sodium sulfonate (AC-17) is an antihemorrhagic for use in the treatment of hemorrhoids. | ||
| M5810 | Neostigmine methyl sulfate | AChR/AChE |
| Neostigmine methyl sulfate is a reversible inhibitor of acetylcholinesterase, can not cross the blood-brain barrier. | ||
| M18441 | 19-Oxocinobufotalin | Others |
| 19-Oxocinobufotalin | ||
| M40282 | δ-Amyrin acetate | Others |
| δ-Amyrin acetate is a terpenoid isolated fromScaevola floribunda. | ||
| M6308 | Ritlecitinib | JAK |
| PF-06651600 | ||
| Ritlecitinib (PF-06651600) is a potent and irreversible JAK3-selective inhibitor with an IC50 of 33.1 nM but without activity (IC50 > 10 000 nM) against JAK1, JAK2, and TYK2. | ||
| M10705 | NVP-2 | CDK |
| NVP-2 is an effective and selective ATP competitive cyclin-dependent kinase 9 (CDK9) probe that inhibits CDK9/CycT activity.IC50 The value is 0.514 nM. NVP-2 has inhibitory effects on CDK1/CycB, CDK2/CycA and CDK16/CycY kinases, which IC50 The values are 0.584 μM, 0.706 μM, and 0.605 μM, respectively. NVP-2 induces apoptosis. | ||
| M11176 | Tebuconazole | Cytochrome P450 (e.g. CYP17) |
| Tebuconazole is an agricultural azole fungicide that also inhibits CYP51 for Candida albicans CYP51 (CaCYP51) and truncated human CYP51 (Δ60HsCYP51). IC50 The values are 0.9 and 1.3 μM, respectively. | ||
| M21513 | Vemurafenib-d7 | Raf |
| PLX4032-d7; RG7204-d7; RO5185426-d7 | ||
| Vemurafenib (PLX4032; RG7204; RO5185426) is a first-in-class selective B-RAF inhibitor that inhibits the activity of RAFV600E and c-RAF-1 with IC50 at 31 nM and 48 nM, respectively. Vemurafenib can induce autophagy. | ||
| M21520 | Vemurafenib-d5 | Raf |
| Vemurafenib (PLX4032; RG7204; RO5185426) is a first-in-class selective B-RAF inhibitor that inhibits the activity of RAFV600E and c-RAF-1 with IC50 at 31 nM and 48 nM, respectively. | ||
| M28022 | SX-517 | CXCR |
| SX-517 is a dual CXCR2/1 antagonist, containing boronic acid. SX-517 inhibits CXCL1-induced Ca2+ flux (IC50=38 nM), and antagonizes CXCL8-induced [(35)S]GTPγS binding (IC50=60 nM) and ERK1/2 phosphorylation. SX-517 has significant ability for inflammation suppression, in both humanized polymorphonuclear (PMN) cells and in murine model. | ||
| M30907 | B-Raf IN 11 | Raf |
| B-Raf IN 11 (ZINC72115182) is a selective B-RafV600E inhibitor (IC50=76 nM), shows selectivity for B-RafV600E over B-RafWT with selectivity of 3.1-fold. B-Raf IN 11 can be used in colorectal cancer research[1] | ||
| M56067 | Ritlecitinib (malonate) | JAK |
| Ritlecitinib (PF-06651600) malonate is an orally active and selective JAK3 inhibitor with an IC50 of 33.1 nM. | ||
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