About 2 results found for searched term "480-11-5" (0.128 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M4460 | Oroxylin-A | CDK |
| Baicalein 6-methyl ether; 6-Methoxybaicalein | ||
| Oroxylin A is an active flavonoid that inhibits the phosphorylation of MDM2 and SIRT1 through the inhibition of CDK9, thus inhibiting MDM2-mediated degradation of P53 and SIRT1-mediated deacetylation of P53, and ultimately stabilizing the P53 protein.Oroxylin A has strong anticancer activity. | ||
| M1942 | Alectinib | ALK |
| CH5424802; AF802 | ||
| Alectinib (CH5424802) is a highly selective, orally active and potent ALK inhibitor with IC50 of 1.9 nM. Alectinib (CH5424802) also inhibits ALK F1174L and ALK R1275Q with IC50s of 1 nM and 3.5 nM, respectively. Alectinib demonstrates effective central nervous system (CNS) penetration. | ||
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