About 1 result found for searched term "313984-77-9" (0.131 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M25487 | PU02 | 5-HT Receptor |
| NMMP | ||
| PU02 (NMMP) is a potent and selective negative allosteric modulator (NAM) of 5-HT3 receptor, displaying IC50 values of ~1 μM at 5-HT(3)Rs and substantially lower activities at other Cys-loop receptors. PU02 inhibits the proliferation of hepatocellular carcinoma (HepG2) cells associated with G2/M phase cell cycle arrest, and reduced cyclin-dependent kinase (CDK) 4 and cyclin B1/D1 levels. | ||
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