About 1 result found for searched term "2893809-51-1" (0.13 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M55031 | BBO-8520 | Ras |
| BBO-8520 is a first-in-class orally active covalent KRAS G12C inhibitor. BBO-8520 inhibits KRASG12C (ON) by locking the GTP-binding protein in state 1, a conformation incapable of binding effectors, thereby inhibiting the downstream signaling of KRASG12C (ON) that promotes cell proliferation. BBO-8520 also rapidly and completely blocks the RAS-RAF1 interaction, returning KRASG12C to its inactive (OFF) state. | ||
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