About 1 result found for searched term "2518299-32-4" (0.148 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M45284 | AMG-548 dihydrochloride | p38 MAPK |
| AMG-548 dihydrochloride is an orally active, selective inhibitor of p38α (Ki=0.5 nM), slightly selective for p38β (Ki=36 nM), and >1000-fold selective for p38γ and p38δ. AMG-548 dihydrochloride also potently inhibits whole blood LPS-stimulated TNFα (IC50=3 nM). LPS-stimulated TNFα (IC50=3 nM). In addition, AMG-548 dihydrochloride inhibits Wnt signaling through direct inhibition of Casein kinase 1 isoforms δ and ε. | ||
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