About 1 result found for searched term "2447066-37-5" (0.061 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M29649 | PROTAC PD-1/PD-L1 degrader-1 | PROTAC |
| PROTAC PD-1/PD-L1 degrader-1, a PD-1/PD-L1 PROTAC based on Cereblon E3 ligand, inhibits PD-1/PD-L1 interaction with an IC50 of 39.2 nM. PROTAC PD-1/PD-L1 degrader-1 significantly restores the immunity repressed in a co-culture model of Hep3B/OS-8/hPD-L1 and CD3 T cells. PROTAC PD-1/PD-L1 degrader-1 moderately reduces the protein levels of PD-L1 in a lysosome-dependent manner. | ||
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