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M10535 Probenecid sodium TRP Channel
Probenecid sodium is a sodium salt of Probenecid that is soluble in water. Probenecid (Benemid) is an organic anionic transport competitive inhibitor, as well as an agonist of transient receptor potential vanillin receptor subfamily 2(TRPV2) and an inhibitor of human bitter taste receptor TAS2R16. Probenecid effectively inhibits the MRP1- and MRP2-mediated uptake of the ATP-dependent active vesicle N-ethylmaleimide-glutathione (NEM-GS). Probenecid can competitively or non-competitively inhibit the transport function of MRP2 for organic anions. In addition to MRP2, probenecid is also an effective inhibitor of MRP1.



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