About 1 result found for searched term "181141-66-2" (0.12 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M28909 | GGTI-286 hydrochloride | Ras |
| GGTI-286 hydrochloride, a potent GGTase I inhibitor, is 25-fold more potent (IC50=2 μM) than the corresponding methyl ester of FTI-276. GGTI-286 hydrochloride selectively inhibits geranylgeranylation of Rap1A over farnesylation of H-Ras in NIH3T3 cells (IC50s =2 and >30 μM, respectively). GGTI-286 hydrochloride also potently inhibits oncogenic K-Ras4B stimulation with an IC50 of 1 μM. | ||
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