About 1 result found for searched term "1336960-13-4" (0.119 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M10625 | GSK2193874 | TRP Channel |
| GSK-2193874; GSK2193874A | ||
| GSK2193874 is a first-in-class orally bioavailable potent antagonist of TRPV4 channels, blocking the influx of calcium induced by the TRPV4 agonist with IC50 values of 2, 5, and 40 nM. GSK2193874 is the first-in-class orally bioavailable TRPV4 inhibitor that demonstrated ability to improve pulmonary functions in a number of heart failure models. | ||
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