About 1 result found for searched term "(S,R)-GSK321" (0.14 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M54531 | (S,R)-GSK321 | Isocitrate Dehydrogenase (IDH) |
| (S,R)-GSK321 is a potent and selective inhibitor of mutant IDH1, inhibiting R132G, R132C, R132H, and WT IDH1 with IC50 values of 2.9, 3.8, 4.6, and 46 nM, respectively, with a 100-fold higher selectivity than IDH2. (S,R)-GSK321 induces a reduction in intracellular 2-HG, failure of myeloid differentiation blockade, and induction of granulocyte differentiation at the level of leukemoblasts and more immature stem cells. (S,R)-GSK321 can be used in studies related to acute myeloid leukemia (AML) and other cancers. | ||
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