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Xentuzumab

Cat. No. M24658

All AbMole products are for research use only, cannot be used for human consumption.

Xentuzumab Structure
Synonym:

BI 836845; Anti-Human IGF1 and IGF2 Recombinant Antibody

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Quality Control & Documentation
Biological Activity

Xentuzumab (Anti-Human IGF1 and IGF2 Recombinant Antibody; BI836845) is a recombinant a humanized monoclonal antibody that targets IGF ligands IGF1 and IGF2. Xentuzumab inhibits both of IGF1 and IGF2 growth-promoting signalling and suppresses AKT activation.

Chemical Information
CAS Number 1417158-65-6
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Peter Schmid, et al. Breast Cancer Res. A phase Ib/II study of xentuzumab, an IGF-neutralising antibody, combined with exemestane and everolimus in hormone receptor-positive, HER2-negative locally advanced/metastatic breast cancer

[2] Ulrike Weyer-Czernilofsky, et al. Mol Cancer Ther. Antitumor Activity of the IGF-1/IGF-2-Neutralizing Antibody Xentuzumab (BI 836845) in Combination with Enzalutamide in Prostate Cancer Models

[3] Zinnia P Parra-Guillen, et al. Clin Pharmacol Ther. Model-Informed Dose Selection for Xentuzumab, a Dual Insulin-Like Growth Factor-I/II-Neutralizing Antibody

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Keywords: Xentuzumab, BI 836845; Anti-Human IGF1 and IGF2 Recombinant Antibody supplier, IGF-1R, inhibitors, activators

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