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TAK-593

Cat. No. M3047
TAK-593 Structure
Size Price Availability Quantity
5mg USD 130  USD130 In stock
10mg USD 205  USD205 In stock
50mg USD 700  USD700 In stock
100mg USD 1120  USD1120 In stock
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Quality Control & Documentation
Biological Activity

TAK-593 is a novel dual VEGFR/PDGFR inhibitor.

Chemical Information
Molecular Weight 445.47
Formula C23H23N7O3
CAS Number 1005780-62-0
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Naoki Miyamoto, et al. Discovery of N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-methylphenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide (TAK-593), a highly potent VEGFR2 kinase inhibitor

[2] Yoshiko Awazu, et al. Anti-angiogenic and anti-tumor effects of TAK-593, a potent and selective inhibitor of vascular endothelial growth factor and platelet-derived growth factor receptor tyrosine kinase

[3] Hidehisa Iwata, et al. Biochemical characterization of TAK-593, a novel VEGFR/PDGFR inhibitor with a two-step slow binding mechanism

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Keywords: TAK-593 supplier, VEGFR/PDGFR, inhibitors, activators


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