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SU4312 unexpectedly prevented MPP(+) -induced neuronal apoptosis in vitro and decreased MPTP-induced loss of dopaminergic neurons, reduced expression of mRNA for tyrosine hydroxylase and impaired swimming behaviour in zebrafish.The neuroprotective actions of SU4312 were independent of its anti-angiogenic action.SU4312 exhibited non-competitive inhibition of purified neuronal NOS (nNOS) with an IC(50) value of 19.0 μM but showed little or no effects on inducible and endothelial NOS.Molecular docking simulations suggested an interaction between SU4312 and the haem group within the active centre of nNOS.
*The compound is unstable in solutions, freshly prepared is recommended
| Molecular Weight | 264.32 |
| Formula | C17H16N2O |
| CAS Number | 5812-07-7 |
| Form | Solid |
| Solubility (25°C) | DMSO 40 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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