Ruthenium red (Ammoniated ruthenium oxychloride) is a polycationic dye widely used for electron microscopy (EM) of cells, tissues and vegetative bacteria. Ruthenium red is also a L-type calcium current (ICa) blocker, blocks Ca2+ uptake and release, and voltage-sensitive Ca2+ channels. Ruthenium red strongly reacts with phospholipids and fatty acids and binds to acidic mucopolysaccharides.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Storage||2-8°C, protect from light, sealed|
|Related Fluorescent Dye Products|
Diphenylterazine is a bioluminescence agent. Diphenylterazine alone yields very little background, leading to excellent signal-to-background ratios. DMSO can inactivate Diphenylterazine's activity
X-Gluc Dicyclohexylamine is used as a reagent to detect β-glucuronidase, an enzyme produced by the E. Coli bacterium; is widely used in molecular biology experiments to mark and select the expression of target genes (GUS reporter system).
|JC-1 Mitochondrial Membrane Potential Assay Kit
JC-1 Mitochondrial Membrane Potential Assay Kit is a kit that uses JC-1 as a fluorescent probe to quickly and sensitively detect the transmembrane potential difference of tissues, cells or purified mitochondria. It can be used for early apoptosis detection.
Rhod-2 AM is a fluorescent, mitochondrial probe (λex=552 nm, λem=581 nm).
|Calcein Red, AM
Calcein AM is one of the most popular fluorescent probes used for labeling and monitoring cellular functions of live cells. Non-fluorescent Calcein Red AM can easily get into live cells and hydrolyzes to generate strongly fluorescent Calcein Red dye. Calcein Red dye can be monitored with the common TRITC/Cy3 filter set.
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