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Rabeprazole

Cat. No. M20434
Rabeprazole Structure
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Rabeprazole is an oral inhibitor of proton pump and blocks the production of acid by the stomach.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 359.44
Formula C18H21N3O3S
CAS Number 117976-89-3
Purity >99%
Solubility DMSO 71 mg/mL
Water 71 mg/mL
Storage at -20°C
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Keywords: Rabeprazole supplier, Proton Pump, inhibitors

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