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Rabeprazole is an oral inhibitor of proton pump and blocks the production of acid by the stomach.
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Molecular Weight | 359.44 |
| Formula | C18H21N3O3S |
| CAS Number | 117976-89-3 |
| Purity | >99% |
| Solubility | DMSO 71 mg/mL Water 71 mg/mL |
| Storage | at -20°C |
| Related Proton Pump Products |
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| Omeprazole Sodium
Omeprazole Sodium is the sodium salt form of omeprazole, which is a proton pump inhibitor and suppresses gastric acid secretion. |
| Ilaprazole sodium
Ilaprazole sodium is the sodium salt form of ilaprazole, which is a proton pump inhibitor. |
| Revaprazan Hydrochloride
Revaprazan Hydrochloride is a new reversible proton pump inhibitor with long-lasting acid-suppressive effects. |
| Pantoprazole
Pantoprazole is a proton pump inhibitor used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease. |
| NEXIUM (esomeprazole magnesium)
Esomeprazole Magnesium is a proton pump inhibitor to reduce gastric acid secretion. |
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