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Porcine dynorphin A (1-13)

Cat. No. M10229
Porcine dynorphin A (1-13) Structure

Dynorphin A Porcine Fragment 1-13

Size Price Availability Quantity
5mg USD 165  USD165 In stock
10mg USD 265  USD265 In stock
25mg USD 543  USD543 In stock
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Quality Control
  • Current batch:
  • Purity >98.5%
  • COA
  • MSDS
Biological Activity

Porcine dynorphin A (1-13) is a potent, endogenous κ opioid receptor agonist. Dynorphin A (1-13) exposure (33 μM) causes a significant loss in neuronal viability at 4 h with a visible destruction in neuronal morphology seen at 16 h. Exposure to dynorphin A (1-13) causes acute increases in [Ca 2+ ] i in individual neurons similar to increases seen with acute NMDA treatment. Continuous exposure to dynorphin A (1-13) (100 μM) causes a significant loss of neurons over time.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 1603.95
Formula C75H126N24O15
CAS Number 72957-38-1
Purity >98.5%
Solubility Water 60 mg/mL
Storage -20°C, sealed

[1] K F Hauser, et al. Exp Neurol. Dynorphin A (1-13) neurotoxicity in vitro: opioid and non-opioid mechanisms in mouse spinal cord neurons

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Keywords: Porcine dynorphin A (1-13), Dynorphin A Porcine Fragment 1-13 supplier, Opioid Receptor, inhibitors

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