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Pomalidomide-PEG4-C-COOH

Cat. No. M9836
Pomalidomide-PEG4-C-COOH Structure
Synonym:

E3 Ligase Ligand-Linker Conjugates 1

Size Price Availability Quantity
100mg USD 435  USD435 In stock
200mg USD 840  USD840 In stock
500mg USD 1680  USD1680 In stock
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Quality Control & Documentation
Biological Activity

Pomalidomide-PEG4-C-COOH (E3 Ligase Ligand-Linker Conjugates 1) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker.

Chemical Information
Molecular Weight 507.49
Formula C23H29N3O10
CAS Number 2097938-44-6
Solubility (25°C) DMSO 41 mg/mL
Ethanol 20 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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Pomalidomide-C7-NH2 hydrochloride

Pomalidomide-C7-NH2 (Pomalidomide 4'-alkylC7-amine) hydrochloride is an E3 ligase ligand-linker conjugate.

Thalidomide-NH-PEG2-C2-NH-Boc 

Thalidomide-NH-PEG2-C2-NH-Boc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a PEG linker used for dBRD9 synthesis. dBRD9 is a selective BRD9 probe PROTAC degrader for the study of BAF complex biology.

Thalidomide-C2-amido-C2-COOH 

Thalidomide-C2-amido-C2-COOH incorporates a CRBN ligand for the E3 ubiquitin ligase, and a linker. Thalidomide-C2-amido-C2-COOH can be used to design PROTAC CDK2/9 Degrader-1.

Thalidomide-O-amido-C4-NH2 (TFA)

Thalidomide-O-amido-C4-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker.

  Catalog
Abmole Inhibitor Catalog




Keywords: Pomalidomide-PEG4-C-COOH, E3 Ligase Ligand-Linker Conjugates 1 supplier, E3 Ligase Ligand-Linker Conjugates, inhibitors, activators


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