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NMS-P715

Cat. No. M27927

All AbMole products are for research use only, cannot be used for human consumption.

NMS-P715 Structure

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Quality Control & Documentation

Purity: ≥99.0%
COA
MSDS

Product Information

Biological Activity

NMS-P715 is a selective, ATP-competitive inhibitor of MPS1, with an IC50 of 182 nM.

Chemical Information

Molecular Weight	676.73
Formula	C35H39F3N8O3
CAS Number	1202055-32-0
Form	Solid
Solubility (25°C)	DMSO 2 mg/mL (ultrasonic)
Storage	Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month

References

[1] Orawan Waenphimai, et al. Eur J Pharmacol. Multiple actions of NMS-P715, the monopolar spindle 1 (MPS1) mitotic checkpoint inhibitor in liver fluke-associated cholangiocarcinoma cells

[2] Yuan Chen, et al. Molecules. Insights into Resistance Mechanisms of Inhibitors to Mps1 C604Y Mutation via a Comprehensive Molecular Modeling Study

[3] Yoshitaka Hiruma, et al. J Biol Chem. Understanding inhibitor resistance in Mps1 kinase through novel biophysical assays and structures

[4] Roger B Slee, et al. Mol Cancer Ther. Selective inhibition of pancreatic ductal adenocarcinoma cell growth by the mitotic MPS1 kinase inhibitor NMS-P715

[5] Riccardo Colombo, et al. Cancer Res. Targeting the mitotic checkpoint for cancer therapy with NMS-P715, an inhibitor of MPS1 kinase

Related Mps1/TTK Products
Luvixasertib hydrochloride CFI-402257 hydrochloride is a highly selective and orally bioavailable TTK/Mps1 inhibitor with an IC50 of 1.7 nM for TTK in vitro.
Mps1-IN-6 Mps1-IN-6 is a potent Mps1 inhibitor with an IC50 value of 2.596 nM.
RMS-07 RMS-07 is a covalent Monopolar Spindle Kinase 1 (MPS1/TTK) inhibitor, with an apparent IC50 of 13.1 nM. RMS-07 targets a poorly conserved cysteine in the kinase's hinge region.
CCT251455 CCT251455 is a potent and selective mitotic kinase monopolar spindle 1 (MPS1) inhibitor with an IC50 of 3 nM.

Catalog

Abmole Inhibitor Catalog

Keywords: NMS-P715 supplier, Mps1/TTK, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.

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