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Miltirone

Cat. No. M17442

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Miltirone Structure
Synonym:

Rosmariquinone

Size Price Availability Quantity
1mg USD 135  USD135 In stock
5mg USD 260  USD260 In stock
10mg USD 400  USD400 In stock
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Biological Activity

Miltirone is an orally active natural compound found in the root of Salvia miltiorrhiza. Miltirone is a central benzodiazepine receptor partial agonist, with an IC50 of 0.3 μM. Miltirone induces ROS - and-p53 dependent apoptosis. Miltirone inhibits carboxylesterase 2 (CES2; Ki = 0.04 μM) and SARS-CoV main protease (Mpro).

Chemical Information
Molecular Weight 282.38
Formula C19H22O2
CAS Number 27210-57-7
Solubility (25°C) DMSO 40 mg/mL
Storage 4°C, protect from light
References

[1] Xiaowei Zhang, et al. Acta Pharm Sin B. Miltirone induces cell death in hepatocellular carcinoma cell through GSDME-dependent pyroptosis

[2] Zhongcheng Zhu. Oncol Lett. Miltirone-induced apoptosis in cisplatin-resistant lung cancer cells through upregulation of p53 signaling pathways

[3] Wei Song, et al. Acta Pharmacol Sin. Pharmacological actions of miltirone in the modulation of platelet function

[4] Lin Wang, et al. Life Sci. Miltirone induced mitochondrial dysfunction and ROS-dependent apoptosis in colon cancer cells

[5] Ling Zhou, et al. Sci Rep. Miltirone exhibits antileukemic activity by ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction pathways

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Keywords: Miltirone, Rosmariquinone supplier, Quinones, inhibitors, activators

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