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MDL 28170

Cat. No. M7934
MDL 28170 Structure
Synonym:

Calpain Inhibitor III

Size Price Availability Quantity
10mg USD 130  USD130 In stock
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Quality Control
Biological Activity

MDL 28170 is a potent cell permeable calpain I and II inhibitor. MDL 28170 reduces capsaicin-mediated cell death in cultured dorsal root ganglion neurons. MDL 28170 reduced occurrence of apoptosis in H2O2 and A23187 treated PC12 cells. γ-secretase-inhibitor.

Product Citations
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 382.45
Formula C22H26N2O4
CAS Number 88191-84-8
Purity >95%
Solubility DMSO: 24 mg/mL
Storage at -20°C
References

[1] Kharatmal SB, et al. Neuropharmacology. Calpain inhibitor, MDL 28170 confer electrophysiological, nociceptive and biochemical improvement in diabetic neuropathy.

[2] Ai J, et al. J Neurotrauma. Calpain inhibitor MDL-28170 reduces the functional and structural deterioration of corpus callosum following fluid percussion injury.

[3] Li PA, et al. Neurosci Lett. Postischemic treatment with calpain inhibitor MDL 28170 ameliorates brain damage in a gerbil model of global ischemia.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: MDL 28170, Calpain Inhibitor III supplier, Proteasome, inhibitors

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