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LOC14 is a potent PDI (protein disulfide isomerase) inhibitor with EC50 value of 500 nM. LOC14 has a Kd value of 62 nM. LOC14 inhibits PDIA3 activity, it also decreases intramolecular disulfide bonds and subsequent oligomerization (maturation) of HA in lung epithelial cells.
In vivo, LOC14 (20 mg/kg/day; gavage; 12-28 weeks) significantly improves motor function, attenuated brain atrophy and extended survival in the N171–82Q HD mice.
| Molecular Weight | 317.41 |
| Formula | C16H19N3O2S |
| CAS Number | 877963-94-5 |
| Solubility (25°C) | DMSO ≥ 25 mg/mL |
| Storage | 2-8°C, protect from light, dry, sealed |
| Related PDI Products |
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| KSC-34
KSC-34, a covalent modifier of protein disulfide isomerase A1 (PDIA1), is also a selective and potent a-site inhibitor of PDIA1 with an IC50 of 3.5 μM. |
| PDI-IN-1
PDI-IN-1 is a cell-permeable human protein disulfide isomerase (PDI) inhibitor with an IC50 of 1.7 μM. |
| 3-Methyltoxoflavin
3-Methyltoxoflavin is a potent Protein disulfide isomerase (PDI) inhibitor, with an IC50 of 170 nM. |
| G6PDi-1
G6PDi-1 is a reversible and non-competitive glucose-6-phosphate dehydrogenase (G6PD) inhibitor with an IC50 of 0.07 μM. G6PDi-1 depletes NADPH most strongly in lymphocytes. G6PDi-1 markedly decreases inflammatory cytokine production in T cells. |
| ML359
ML359 is a potent, selctive and reversible inhibitor of protein disulfide isomerase (PDI), with an IC50 of 250 nM. ML359 can prevent thrombus formation in vivo. |
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