Lercanidipine is a lipophilic third-generation dihydropyridine-calcium channel blocker (DHP-CCB). Lercanidipine has long lasting antihypertensive action and reno-protective effect.
| Molecular Weight | 611.73 |
| Formula | C36H41N3O6 |
| CAS Number | 100427-26-7 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] Cherylyn Beckey, et al. Ann Pharmacother. Lercanidipine in the treatment of hypertension
[3] Claudio Borghi. Vasc Health Risk Manag. Lercanidipine in hypertension
[4] Philip I Hair, et al. Drugs. Fixed-dose combination lercanidipine/enalapril
[5] K J McClellan, et al. Drugs. Lercanidipine: a review of its use in hypertension
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